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Cyclooxygenase-2 is Involved in the Progression of Thyroid Cancer


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タイトル: Cyclooxygenase-2 is Involved in the Progression of Thyroid Cancer
著者: Sugahara, Ikuko / Ando, Takao / Usa, Toshiro / Kawakami, Atsushi / Ashizawa, Kiyoto / Uga, Tatsuya / Maeda, Shigeto / Kanematsu, Takashi / Eguchi, Katsumi
発行日: 2009年 7月
引用: Acta medica Nagasakiensia, 54(1), pp.9-14 ; 2009
抄録: Although the inducible form of cyclooxygenase (COX), COX-2, is highly expressed in various cancers and it is also involved in cancer progression, its role in thyroid cancer is not fully understood. We assessed in the situ cyclooxygenase expression in normal thyroids (n=6), Graves' thyroids (n=6), thyroid adenomas (n=12), thyroid follicular (n=15) and papillary carcinomas (n=30). In comparison to the constitutive expression of COX-1, COX-2 was highly expressed in thyroid cancers (90.0% of thyroid papillary carcinomas and 73.3% of thyroid follicular carcinomas) and moderately in thyroid adenomas (25.5%), but barely expressed in normal and Graves' thyroid tissues. This quantitative assessment employed immunohistochemical methods. Thereafter we compared the effect of COX-2 inhibition on a human follicular thyroid carcinoma cell line (WRO), and a human papillary carcinoma cell line (NPA), using selective COX-2 inhibitor(NS-398). The treatment with 50 μM NS-398 suppressed the growth of the COX-2 expressing cells, NPA cells (37.7%;p<0.01) and WRO cells (10.1%;p<0.05). Moreover, at concentrations ? 100 μM, NS-398 induced cell death a mitochondrial dysfunction. In addition, 50 μM of NS-398 inhibited the activation of extracellular signal-regulated kinase in NPA cells after the stimulation with fetal bovine serum. Our results indicate that COX-2 is involved in the progression of thyroid cancer.
キーワード: Cyclooxygenase-2 (COX-2) / Thyroid cancer / COX-2 inhibitor / Apoptosis / Mitogen-activated protein kinase
URI: http://hdl.handle.net/10069/22060
ISSN: 00016057
関連リンク : http://joi.jlc.jst.go.jp/JST.JSTAGE/amn/54.9
資料タイプ: Departmental Bulletin Paper
原稿種類: publisher
出現コレクション:Volume 54, No. 1

引用URI : http://hdl.handle.net/10069/22060

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