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Single amino acid substitution in Plasmodium yoelii erythrocyte ligand determines its localization and controls parasite virulence


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タイトル: Single amino acid substitution in Plasmodium yoelii erythrocyte ligand determines its localization and controls parasite virulence
著者: Otsuki, Hitoshi / Kaneko, Osamu / Thongkukiatkul, Amporn / Tachibana, Mayumi / Iriko, Hideyuki / Takeo, Satoru / Tsuboi, Takafumi / Torii, Motomi
発行日: 2009年 4月28日
出版者: the National Academy of Sciences
引用: PNAS, 106(17), pp.7167-7172; 2009
抄録: The major virulence determinant of the rodent malaria parasite, Plasmodium yoelii, has remained unresolved since the discovery of the lethal line in the 1970s. Because virulence in this parasite correlates with the ability to invade different types of erythrocytes, we evaluated the potential role of the parasite erythrocyte binding ligand, PyEBL. We found 1 amino acid substitution in a domain responsible for intracellular trafficking between the lethal and nonlethal parasite lines and, furthermore, that the intracellular localization of PyEBL was distinct between these lines. Genetic modification showed that this substitution was responsible not only for PyEBL localization but also the erythrocyte-type invasion preference of the parasite and subsequently its virulence in mice. This previously unrecognized mechanism for altering an invasion phenotype indicates that subtle alterations of a malaria parasite ligand can dramatically affect host–pathogen interactions and malaria virulence.
キーワード: erythrocyte / invasion / ligand / malaria / Plasmodium yoelii
URI: http://hdl.handle.net/10069/22077
ISSN: 00278424
DOI: 10.1073/pnas.0811313106
PubMed ID: 19346470
権利: Copyright ©2009 by the National Academy of Sciences
資料タイプ: Journal Article
原稿種類: author
出現コレクション:120 学術雑誌論文

引用URI : http://hdl.handle.net/10069/22077

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