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Time-course expression profiles of hair cycle-associated genes in male mini rats after depilation of telogen-phase hairs.


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タイトル: Time-course expression profiles of hair cycle-associated genes in male mini rats after depilation of telogen-phase hairs.
著者: Umeda-Ikawa, Aya / Shimokawa, Isao / Doi, Kunio
発行日: 2009年 5月
出版者: Molecular Diversity Preservation International
引用: International Journal of Molecular Sciences.10(5), pp.1967-1977; 2009
抄録: Jcl:WistarTGN(ARGHGEN)1Nts rat (Mini rat) is a growth hormone (GH)-deficient transgenic rat. The hair cycle in the dorsal skin of male Mini rats enters a long-lasting telogen phase after eights weeks of age, but depilation can induce a transient hair cycle again. In this study, a time-course profiling of genes expression was done on the dorsal skin of male Mini rats along the progression of depilation-induced hair cycle using DNA microarray analysis. As a result, 1,215 probe sets including 1,171 hair cycle-related ones showed more than 3-fold changes in expression compared with that in before-depilation telogen phase. The present data will contribute to elucidating the mechanisms of hair cycle regulation and should lead to the identification of novel molecular targets for hair growth and/or depilation agents.
キーワード: GH-deficient Mini rats / dorsal skin / hair cycle / microarray analysis
URI: http://hdl.handle.net/10069/22083
DOI: 10.3390/ijms10051967
PubMed ID: 19564932
権利: © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:030 学術雑誌論文

引用URI : http://hdl.handle.net/10069/22083

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