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Efficacy of linezolid against Panton-Valentine leukocidin (PVL)-positive meticillin-resistant Staphylococcus aureus (MRSA) in a mouse model of haematogenous pulmonary infection.


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Title: Efficacy of linezolid against Panton-Valentine leukocidin (PVL)-positive meticillin-resistant Staphylococcus aureus (MRSA) in a mouse model of haematogenous pulmonary infection.
Authors: Yanagihara, Katsunori / Kihara, Rie / Araki, Nobuko / Morinaga, Yoshitomo / Seki, Masafumi / Izumikawa, Koichi / Kakeya, Hiroshi / Yamamoto, Yoshihiro / Yamada, Yasuaki / Kohno, Shigeru / Tsukamoto, Kazuhiro / Kamihira, Shimeru
Issue Date: Nov-2009
Citation: International journal of antimicrobial agents, 34(5), pp.477-481; 2009
Abstract: Many strains of community-acquired meticillin-resistant Staphylococcus aureus (MRSA) have a pore-forming leukotoxin, known as Panton-Valentine leukocidin (PVL), which can cause severe necrotising pneumonia. Linezolid (LZD) is a new antibacterial agent with potent antibacterial activity against MRSA. In this study, a mouse model of haematogenous pulmonary infection was used to compare the efficacies of LZD and vancomycin (VAN) against pulmonary infection caused by PVL-positive S. aureus. Following antibiotic administration for 3 days, the number of viable bacteria (mean+/-standard error of the mean) in the control, VAN and LZD groups was 6.77+/-0.14, 5.29+/-0.27 and 4.25+/-0.33log colony-forming units/lung, respectively. LZD significantly decreased the number of viable bacteria in the lungs compared with the control and VAN groups (P<0.05). The survival rate at Day 7 post-inoculation was higher in the LZD group (100%) than in the VAN group (50%) or the control group (0%). Histopathological examination and cytokine analysis also showed the beneficial efficacy of LZD compared with VAN. In conclusion, LZD significantly reduced bacterial numbers and inflammation in a mouse model of PVL-positive S. aureus haematogenous infection and improved the survival rate of infected mice compared with VAN. LZD is clinically effective against PVL-positive S. aureus.
Keywords: pathogenesis / resistant bacteria / MRSA / linezolid
URI: http://hdl.handle.net/10069/22096
ISSN: 18727913
DOI: 10.1016/j.ijantimicag.2009.06.024
PubMed ID: 19665359
Rights: Copyright © 2009 Elsevier B.V. and the International Society of Chemotherapy
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/22096

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