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Elevation of Serum KL-6 Glycoprotein or Surfactant Protein-D in Adult T-cell Leukemia with Distinct Pulmonary Complications

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Title: Elevation of Serum KL-6 Glycoprotein or Surfactant Protein-D in Adult T-cell Leukemia with Distinct Pulmonary Complications
Authors: Osaka, Akemi / Yanagihara, Katsunori / Yamada, Yasuaki / Hasegawa, Hiroo / Inokuchi, Naoko / Hayashi, Tomayoshi / Komoda, Minori / Nakamura, Shigeki / Aoyama, Muneo / Sawada, Takashi / Kamihira, Shimeru
Issue Date: Jun-2009
Publisher: Tohoku University
Citation: The Tohoku Journal of Experimental Medicine, 218(2), pp.99-105
Abstract: Patients with hematological malignancies frequently suffer from lung diseases as a complication. However, it is difficult to discriminate leukemic invasion into the lung from infectious pulmonary complications. The serum level of Krebs von den Lungen-6 (KL-6), which is a mucin-like glycoprotein, is increased in more than 70% of patients with interstitial pneumonia. Surfactant protein-D (SP-D) is produced mainly in the lung by alveolar type II and bronchiolar epithelial cells and is a useful serum marker for interstitial pneumonia. We therefore measured the levels of KL-6 and SP-D in sera from 128 patients (76 males and 52 females, mean age: 59 years) with hematological malignancies, including adult T-cell leukemia (ATL). Overall, the increase in KL-6 or SP-D, above each cut-off value (500 U/ml for KL-6 and 110 ng/ml for SP-D), was detected in 11 patients (8.6%) or 10 patients (7.8%), respectively. In contrast, among 67 ATL patients, 15 patients had high serum levels of KL-6 and/or SP-D; both were elevatedin 2 patients, only KL-6 was elevated in 6 patients and only SP-D was elevated in 7 patients. Thus, serum KL-6 and SP-D appear to be elevated in a mutually exclusive manner in ATL. Indeed, high serum levels of KL-6 were closely related to the stage of ATL, while the serum SP-D was elevated in ATL patients with pulmonary infection. In conclusion, the combined measurement of KL-6 and SP-D in ATL may become a useful means to discriminate leukemic pulmonary lesions from infectious pulmonary complications.
Keywords: Adult T-cell leukemia / Hematological malignancy / Interstitial pneumonia / Krebs von den Lungen-6 / Surfactant protein-D
URI: http://hdl.handle.net/10069/22168
ISSN: 00408727
DOI: 10.1620/tjem.218.99
Rights: © 2009 Tohoku University Medical Press.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/22168

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