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Title: 肝臓表面からの吸収を利用した薬物送達システムの開発とその展開
Other Titles: Development of Drug Delivery System by Utilizing Absorption from Liver Surface and Its Application
Authors: 西田, 孝洋
Authors (alternative): Nishida, Koyo
Issue Date: Aug-2009
Publisher: 日本薬学会
Citation: Yakugaku Zasshi, 129(8), pp.925-932; 2009
Abstract: Because it is difficult to achieve local drug activity following administration by the conventional intravenous and oral routes, I sought to develop a new route of administration utilizing drug absorption from the liver surface in order to target that organ. Although direct application to the liver surface should yield local drug distribution, drug absorption from the liver surface has not been reported in the literature. Therefore, we analyzed, as a model, the efficiency of absorption of several organic anions and dextrans of various molecular weights following application to the rat liver surface in vivo using a cylindrical diffusion cell. Each compound appeared gradually in the plasma, followed by excretion into the bile and/or urine, indicating the possibility of drug absorption from the liver surface. The absorption process from the liver surface may not involve a specific transport system because dose and transport inhibitors had no detectable effect. In addition, molecular weight was found to be a determinant of absorption through the liver surface. The efficiency of targeting desired region in the liver was enhanced considerably by application to the liver surface, compared to intravenous administration. Moreover, I have obtained several promising results from the application of this new drug delivery system to anticancer drugs and gene therapy. On the other hand, I have also clarified the characteristics of drug absorption from the surfaces of the kidney, stomach, cecum and small intestine, and plan to apply the physiological findings to other fields.
Keywords: drug targeting / administration route / absorption / organ surface / physicochemical property
URI: http://hdl.handle.net/10069/22182
ISSN: 00316903
DOI: 10.1248/yakushi.129.925
PubMed ID: 19652498
Rights: Copyright (c) 2009 by the PHARMACEUTICAL SOCIETY OF JAPAN
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/22182

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