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Hybrid male sterility is caused by mitochondrial DNA deletion.


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タイトル: Hybrid male sterility is caused by mitochondrial DNA deletion.
著者: Hayashida, Kenji / Kohno, Shigeru
発行日: 2009年 7月
出版者: Springer Netherlands
引用: Molecular biology reports, 36(6), pp.1365-1369; 2009
抄録: Although it is known that the hybrid male mouse is sterile just like any other animal's heterogametic sex, the reason why only the male germ cells are impaired has yet to be discovered. TdT-mediated dUTP nick end labeling assay using a confocal fluorescence microscope and DNA fragmentation assay of hybrid testis indicated destruction of the mitochondrial DNA (mtDNA) rather than the nuclear DNA. Previously we reported that maternal mtDNA inheritance is through selective sperm mtDNA elimination based on the sperm factor and two egg factors, and expression of these three factors was recognized in the hybrid testis. It was thereby assumed that mtDNA destruction caused by the expression of maternal mtDNA inheritance system in male germ cells is implicated in the hybrid male sterility of mice.
キーワード: Eri15 / Hybrid male sterility / Maternal Mitochondrial DNA inheritance / Mitochondrial DNA deletion / Postzygotic reproductive isolation / Spag1 / Speciation / TUNEL assay
URI: http://hdl.handle.net/10069/22201
ISSN: 03014851
DOI: 10.1007/s11033-008-9321-5
PubMed ID: 18649010
権利: © 2008 Springer Science+Business Media B.V. / The original publication is available at www.springerlink.com
資料タイプ: Journal Article
原稿種類: author
出現コレクション:030 学術雑誌論文

引用URI : http://hdl.handle.net/10069/22201

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