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Foxp3 expression on normal and leukemic CD4+CD25+ T cells implicated in human T-cell leukemia virus type-1 is inconsistent with Treg cells

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タイトル: Foxp3 expression on normal and leukemic CD4+CD25+ T cells implicated in human T-cell leukemia virus type-1 is inconsistent with Treg cells
著者: Abe, Masaki / Uchihashi, Kinya / Tsuruda, Kazuto / Osaka, Akemi / Yanagihara, Katsunori / Hasegawa, Hiroo / Yamada, Yasuaki / Kamihira, Shimeru
発行日: 2008年 9月
出版者: Blackwell Publishing Inc.
引用: European Journal of Haematology, 81(3) pp.209-217; 2008
抄録: Foxp3 is a master gene of Treg cells, a novel subset of CD4+ T cells primarily expressing CD25. We describe here different features in Foxp3 expression profile between normal and leukemic CD4+CD25+ T cells, using peripheral blood samples from healthy controls (HCs), human T-cell leukemia virus type-1 (HTLV-1)-infected asymptomatic carriers (ACs), patients with adult T-cell leukemia (ATL), and various hematopoietic cell lines. The majority of CD4+CD25+ T cells in HCs were positive for Foxp3, but not all CD4+CD25+ T cells in ACs were positive, indicating that Foxp3 expression is not always linked to CD25 expression in normal T cells. Leukemic (ATL) T cells constitutively expressing CD25 were characteristic of heterogeneous Foxp3 expression, such as intra- and inter-case heterogeneity in intensity, inconsistency with CD25 expression, and a discrepancy in the mRNA and its protein expression. Surprisingly, a discernible amount of Foxp3 mRNA was detectable even in most cell lines without CD25 expression, a small fraction of which was positive for the Foxp3 proteins. The subcellular localization of Foxp3 in HTLV-1-infected cell lines was mainly cytoplasmic, different from that of primary ATL cells. These findings indicate that Foxp3 has two facets: essential Treg identity and molecular mimicry secondary to tumorigenesis. Conclusively, Foxp3 in normal T cells, but not mRNA, is basically potent at discriminating a subset of Treg cells from CD25 + T-cell populations, whereas the modulation of Foxp3 expression in leukemic T cells could be implicated in oncogenesis and has a potentially useful clinical role.
キーワード: Adult T-cell leukemia / CD25 / Foxp3 / Human T-cell leukemia virus type-1 / Treg
URI: http://hdl.handle.net/10069/22222
ISSN: 09024441
DOI: 10.1111/j.1600-0609.2008.01105.x
権利: (c) 2008 Blackwell Munksgaard / The definitive version is available at www.blackwell-synergy.com
資料タイプ: Journal Article
原稿種類: author
出現コレクション:110 学術雑誌論文

引用URI : http://hdl.handle.net/10069/22222



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