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Molecular pathology of RUNX3 in human carcinogenesis.


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タイトル: Molecular pathology of RUNX3 in human carcinogenesis.
著者: Subramaniam, Manish Mani / Chan, Jason Yongsheng / Yeoh, Khay Guan / Quek, Timothy / Ito, Kosei / Salto-Tellez, Manuel
発行日: 2009年12月
出版者: Elsevier BV
引用: Biochimica et Biophysica Acta - Reviews on Cancer, 1796(2), pp.315-331; 2009
抄録: A major goal of molecular biology is to elucidate the mechanisms underlying cancer development and progression in order to achieve early detection, better diagnosis and staging and novel preventive and therapeutic strategies. We feel that an understanding of Runt-related transcription factor 3 (RUNX3)-regulated biological pathways will directly impact our knowledge of these areas of human carcinogenesis. The RUNX3 transcription factor is a downstream effector of the transforming growth factor-beta (TGF-beta) signaling pathway, and has a critical role in the regulation of cell proliferation and cell death by apoptosis, and in angiogenesis, cell adhesion and invasion. We previously identified RUNX3 as a major gastric tumor suppressor by establishing a causal relationship between loss of function and gastric carcinogenesis. More recently, we showed that RUNX3 functions as a bona fide initiator of colonic carcinogenesis by linking the Wnt oncogenic and TGF-beta tumor suppressive pathways. Apart from gastric and colorectal cancers, a multitude of epithelial cancers exhibit inactivation of RUNX3, thereby making it a putative tumor suppressor in human neoplasia. This review highlights our current understanding of the molecular mechanisms of RUNX3 inactivation in the context of cancer development and progression.
キーワード: Apoptosis; Cancer / Carcinogenesis / Epigenetics / Methylation / Oncogene / Preneoplastic lesions / Protein expression / RUNX / RUNX3 / Tumor suppressor gene
URI: http://hdl.handle.net/10069/22223
ISSN: 0304419X
DOI: 10.1016/j.bbcan.2009.07.004
PubMed ID: 19682550
権利: © 2009 Elsevier B.V. All rights reserved.
資料タイプ: Journal Article
原稿種類: author
出現コレクション:110 学術雑誌論文

引用URI : http://hdl.handle.net/10069/22223

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