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Exacerbation of autoimmune thyroiditis by a single low dose of whole-body irradiation in non-obese diabetic-H2(h4) mice.


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Title: Exacerbation of autoimmune thyroiditis by a single low dose of whole-body irradiation in non-obese diabetic-H2(h4) mice.
Authors: Nagayama, Yuji / Kaminoda, Kazuhisa / Mizutori, Yumiko / Saitoh, Ohki / Abiru, Norio
Issue Date: Sep-2008
Publisher: Taylor & Francis
Citation: International Journal of Radiation Biology, 84(9), pp.761-769; 2008
Abstract: Purpose: To evaluate how irradiation affects thyroid autoimmunity in mouse models of Hashimoto's thyroiditis and Graves' hyperthyroidism. Materials and methods: Non-obese diabetic (NOD)-H2(h4) mice spontaneously develop anti-thyroglobulin (Tg) antibodies and thyroiditis when supplied with sodium iodine (NaI) in the drinking water. BALB/c mice develop anti-thyrotropin receptor (TSHR) antibodies and hyperthyroidism following immunization with adenovirus expressing TSHR (Ad-TSHR). Mice were irradiated as follows: A single whole-body irradiation with 0.05, 0.5 or 3 Gy one week before or after the beginning of NaI or immunization with Ad-TSHR, fractionated whole-body irradiations with 0.05 Gy twice a week or 0.5 Gy once a week from one week before NaI or Ad-TSHR immunization, or a single regional irradiation to the thyroid gland with 0.5 Gy one week before NaI. The effect of a single irradiation with 0.05, 0.5 or 3 Gy on splenocytes was also evaluated. Results: A single whole-body irradiation with 0.5 Gy one week before NaI exacerbated thyroiditis and increased anti-Tg antibody titers in NOD-H2(h4) mice. In contrast, any irradiation protocols employed did not affect incidence of hyperthyroidism or anti-TSHR antibody titers in BALB/c mice. High-dose irradiation increased the relative ratios of effector T cells to regulatory T cells (an indication of enhanced immune status) but kills most of T cells. Conclusions: These results indicate that a single whole-body low-dose irradiation with 0.5 Gy exacerbates thyroiditis in NOD-H2(h4) mice, data consistent with some clinical evidence for increased incidence of thyroid autoimmunity by environmental irradiation.
Keywords: Adenovirus / Iodide / Thyroglobulin / Thyroid autoimmunity / Thyrotropin receptor
URI: http://hdl.handle.net/10069/22224
ISSN: 09553002
DOI: 10.1080/09553000802345910
PubMed ID: 18821390
Rights: This is an electronic version of an article published in International Journal of Radiation Biology, 2008, 84(9), p.761-769. International Journal of Radiation Biology is available online at: http://www.informaworld.com/openurl?genre=article&doi:10.1080/09553000802345910
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/22224

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