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An experience of hepatopancreatoduodenectomy in patients with hepatobiliary malignancies

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Title: An experience of hepatopancreatoduodenectomy in patients with hepatobiliary malignancies
Authors: Nanashima, Atsushi / Nagasaki, Toshiya / Sumida, Yorihisa / Abo, Takafumi / Tobinaga, Syuuichi / Takeshita, Hiroaki / Nonaka, Takashi / Hidaka, Shigekazu / Sawai, Terumitsu / Yasutake, Toru / Nagayasu, Takeshi
Issue Date: Sep-2008
Publisher: Thieme
Citation: Hepato-Gastroenterology, 55(86-87), pp.1691-1694; 2008
Abstract: BACKGROUND/AIMS: In the advanced stage of hepatobiliary malignancies, concurrent hepatopancreatoduodenectomy (HPD) is necessary to accomplish curative resection, even though high rates of morbidity and mortality still remain. METHODOLOGY: We examined the surgical records and outcome in 11 patients undergoing HPD. RESULTS: In 11 patients, diseases included bile duct carcinomas in 7 patients, gallbladder carcinomas in 3, and ampullar carcinoma in one. Hemi-hepatectomy with resection of the caudate lobe was performed in 8 patients and resection of segment 4 and 5 of the liver in two. Pancreatoduodenectomy (PD) was performed in 3 patients and pylorus-preserving PD in 8. Curative resection was accomplished in 8 patients. Two patients underwent adjuvant photodynamic therapy because of a cancer-positive margin. Morbidity rate was 36% but no hospital deaths were reported. The tumor recurrence rate was 73% and 8 patients died of cancer. Patient prognosis of gallbladder cancers (12 +/- 1 months) tended to be shorter than in patients with bile duct cancers (19 +/- 11 months) (p=0.15). Three patients with bile duct cancers survived without tumor relapse over 12 months. CONCLUSIONS: Complete surgical resection (R0) by HPD could be safely performed for diseases of the hepatobiliary malignancies, which achieved longer survival in some patients.
Keywords: Biliary malignancy / Hepatectomy / Pancreato-duodenectomy
URI: http://hdl.handle.net/10069/22225
ISSN: 01726390
PubMed ID: 19102371
Rights: Copyright 2008 Thieme Publishing
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/22225

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