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In vivo efficacy of sitafloxacin in a new murine model of non-typeable Haemophilus influenzae pneumonia by sterile intratracheal tube.


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Title: In vivo efficacy of sitafloxacin in a new murine model of non-typeable Haemophilus influenzae pneumonia by sterile intratracheal tube.
Authors: Nakamura, Shigeki / Yanagihara, Katsunori / Araki, Nobuko / Morinaga, Yoshitomo / Izumikawa, Koichi / Seki, Masafumi / Kakeya, Hiroshi / Yamamoto, Yoshihiro / Kamihira, Shimeru / Kohno, Shigeru
Issue Date: Sep-2009
Publisher: Elsevier
Citation: International Journal of Antimicrobial Agents, 34(3), pp.210-214; 2009
Abstract: A novel murine model of non-typeable Haemophilus influenzae (NTHi) pneumonia was established. A plastic tube was inserted into the trachea 7 days before bacterial inoculation. Numbers of NTHi recovered from the lungs and trachea were determined for 7 days. Histologically, bronchioles and adjacent alveoli in the intubation group were filled with numerous inflammatory cells. The efficacy of sitafloxacin was compared with ciprofloxacin using the new murine pneumonia model. The data suggest that sitafloxacin displays equivalent efficacy to ciprofloxacin against H. influenzae pneumonia. This new murine NTHi pneumonia model appears useful not only for in vivo evaluation of antibiotics but also for analysis of the pathogenesis of H. influenzae pneumonia.
Keywords: Haemophilus influenzae / Non-typeable / Sitafloxacin / Sterile intratracheal tube
URI: http://hdl.handle.net/10069/22244
ISSN: 18727913
DOI: 10.1016/j.ijantimicag.2009.03.011
PubMed ID: 19394203
Rights: Copyright (c) 2009 Elsevier Inc. All rights reserved.
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/22244

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