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In vivo efficacy of sitafloxacin in a new murine model of non-typeable Haemophilus influenzae pneumonia by sterile intratracheal tube.


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タイトル: In vivo efficacy of sitafloxacin in a new murine model of non-typeable Haemophilus influenzae pneumonia by sterile intratracheal tube.
著者: Nakamura, Shigeki / Yanagihara, Katsunori / Araki, Nobuko / Morinaga, Yoshitomo / Izumikawa, Koichi / Seki, Masafumi / Kakeya, Hiroshi / Yamamoto, Yoshihiro / Kamihira, Shimeru / Kohno, Shigeru
発行日: 2009年 9月
出版者: Elsevier
引用: International Journal of Antimicrobial Agents, 34(3), pp.210-214; 2009
抄録: A novel murine model of non-typeable Haemophilus influenzae (NTHi) pneumonia was established. A plastic tube was inserted into the trachea 7 days before bacterial inoculation. Numbers of NTHi recovered from the lungs and trachea were determined for 7 days. Histologically, bronchioles and adjacent alveoli in the intubation group were filled with numerous inflammatory cells. The efficacy of sitafloxacin was compared with ciprofloxacin using the new murine pneumonia model. The data suggest that sitafloxacin displays equivalent efficacy to ciprofloxacin against H. influenzae pneumonia. This new murine NTHi pneumonia model appears useful not only for in vivo evaluation of antibiotics but also for analysis of the pathogenesis of H. influenzae pneumonia.
キーワード: Haemophilus influenzae / Non-typeable / Sitafloxacin / Sterile intratracheal tube
URI: http://hdl.handle.net/10069/22244
ISSN: 18727913
DOI: 10.1016/j.ijantimicag.2009.03.011
PubMed ID: 19394203
権利: Copyright (c) 2009 Elsevier Inc. All rights reserved.
資料タイプ: Journal Article
原稿種類: author
出現コレクション:130 学術雑誌論文

引用URI : http://hdl.handle.net/10069/22244

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