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Simvastatin attenuates trinitrobenzene sulfonic acid-induced colitis, but not oxazalone-induced colitis.


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Title: Simvastatin attenuates trinitrobenzene sulfonic acid-induced colitis, but not oxazalone-induced colitis.
Authors: Ikeda, Maho / Takeshima, Fuminao / Isomoto, Hajime / Shikuwa, Saburo / Mizuta, Yohei / Ozono, Yoshiyuki / Kohno, Shigeru
Issue Date: Jul-2008
Publisher: Springer Netherlands
Citation: Digestive diseases and sciences, 53(7), pp.1869-1875; 2008
Abstract: PURPOSE: To determine whether simvastatin is able to inhibit inflammation in trinitrobenzene sulfonic acid (TNBS)-induced or oxazalone (OXA)-induced colitis. RESULTS: In the prophylactic protocol, simvastatin dose-dependently suppressed the decrease in body weight and inflammatory grade of TNBS-treated mice. In contrast, in the therapeutic protocol, no significant difference in body weight reduction was observed between simvastatin-treated and control mice. IFN-gamma release from LP cells was significantly suppressed in mice receiving high-dose simvastatin in the prophylactic protocol. In contrast to TNBS colitis, even high-dose prophylactic simvastatin had no suppressive effects on either weight reduction or the inflammatory grade in OXA colitis. CONCLUSION: Our results indicate that simvastatin negatively regulates inflammation in TNBS-induced colitis, but not in OXA-induced colitis. In TNBS-induced colitis, simvastatin suppressed the Th1-polarized immune response. Our findings suggest that simvastatin has potential effects as a therapeutic agent in human inflammatory bowel disease, particularly Crohn's disease.
Keywords: Colitis / Simvastatin / Statin / TNBS
URI: http://hdl.handle.net/10069/22287
ISSN: 01632116
DOI: 10.1007/s10620-007-0102-0
PubMed ID: 18049901
Rights: © Springer Science+Business Media, LLC 2007 / The original publication is available at www.springerlink.com
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/22287

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