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In vitro activity of garenoxacin against Streptococcus pneumoniae mutants with characterized resistance mechanisms.


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Title: In vitro activity of garenoxacin against Streptococcus pneumoniae mutants with characterized resistance mechanisms.
Authors: Yamamoto, Kazuko / Yanagihara, Katsunori / Sugahara, Kazuyuki / Imamura, Yoshifumi / Seki, Masafumi / Izumikawa, Koichi / Kakeya, Hiroshi / Yamamoto, Yoshihiro / Hirakata, Yoichi / Kamihira, Shimeru / Kohno, Shigeru
Issue Date: Aug-2009
Publisher: American Society for Microbiology
Citation: Antimicrobial agents and chemotherapy, 53(8), pp.3572-3575; 2009
Abstract: We evaluated the potency of garenoxacin in selecting resistant Streptococcus pneumoniae mutants by determining its mutant prevention concentration, using strains with and without topoisomerase gene mutations, and compared its potency to that of other quinolones. Garenoxacin had a significantly greater potency against pneumococci, including strains containing topoisomerase mutations. Genetic analysis of the S. pneumoniae mutants created by garenoxacin revealed that the gyrA gene was a primary target of garenoxacin.
URI: http://hdl.handle.net/10069/22297
ISSN: 00664804
DOI: 10.1128/AAC.00176-09
PubMed ID: 19451290
Rights: Copyright © 2009, American Society for Microbiology. All Rights Reserved.
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/22297

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