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Simvastatin suppresses the differentiation of C2C12 myoblast cells via a Rac pathway.


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タイトル: Simvastatin suppresses the differentiation of C2C12 myoblast cells via a Rac pathway.
著者: Baba, Tomomi T / Nemoto, Takayuki K / Miyazaki, Toshihiro / Oida, Shinichiro
発行日: 2008年 5月
出版者: Springer Netherlands
引用: Journal of muscle research and cell motility, 29(2-5), pp.127-134; 2008
抄録: Statins, which are known as cholesterol-lowering drugs, have several additional effects including the enhancement of bone formation and the stimulation of smooth muscle cell proliferation. In this study, we investigated the signal pathway of simvastatin operating in C2C12 myoblast cells. Myotube formation of C2C12 cells was efficiently blocked by 1 muM simvastatin, and mevalonic acid was able to cancel this effect. Geranylgeranyl pyrophosphate restored the myotube formation, whereas farnesyl pyrophosphate did not. These findings demonstrate that the Rho family, such as Rho, Rac and Cdc42, occurring downstream of geranylgeranyl pyrophosphate in the mevalonic acid pathway, was involved in the simvastatin-mediated blockage of myotube formation. An inhibitor of Rho kinase did not influence the myotube formation; whereas an inhibitor of Rac blocked this process. Taken together, we conclude that the differentiation of C2C12 cells into myotubes was blocked by simvastatin through the pathway mediated by Rac, not by Rho.
キーワード: C2C12 / Cholesterol-lowering drugs / Myoblast / Myogenin / Myotube / Statins
URI: http://hdl.handle.net/10069/22301
ISSN: 01424319
DOI: 10.1007/s10974-008-9146-9
PubMed ID: 18792797
権利: © Springer Science+Business Media B.V. 2008 / The original publication is available at www.springerlink.com
資料タイプ: Journal Article
原稿種類: author
出現コレクション:040 学術雑誌論文

引用URI : http://hdl.handle.net/10069/22301

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