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Efficacy of combination antifungal therapy with intraperitoneally administered micafungin and aerosolized liposomal amphotericin B against murine invasive pulmonary aspergillosis.


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Title: Efficacy of combination antifungal therapy with intraperitoneally administered micafungin and aerosolized liposomal amphotericin B against murine invasive pulmonary aspergillosis.
Authors: Takazono, Takahiro / Izumikawa, Koichi / Mihara, Tomo / Kosai, Kosuke / Saijo, Tomomi / Imamura, Yoshifumi / Miyazaki, Taiga / Seki, Masafumi / Kakeya, Hiroshi / Yamamoto, Yoshihiro / Yanagihara, Katsunori / Kohno, Shigeru
Issue Date: Aug-2009
Publisher: American Society for Microbiology
Citation: Antimicrobial agents and chemotherapy, 53(8), pp.3508-3510; 2009
Abstract: Targeted intrapulmonary delivery of drugs may reduce systemic toxicity and improve treatment efficacy. In the current study, we evaluated the effects of a combination treatment consisting of inhalation of aerosolized liposomal amphotericin B (L-AMB) with intraperitoneal administration of micafungin (MCFG) against murine invasive pulmonary aspergillosis. The combination of aerosolized L-AMB with intraperitoneal MCFG significantly improved the survival rate, and the fungal burdens and histopathology findings after this treatment were superior to those of the control and both monotherapy groups.
URI: http://hdl.handle.net/10069/22310
ISSN: 00664804
DOI: 10.1128/AAC.00285-09
PubMed ID: 19528281
Relational Links: http://hdl.handle.net/10069/26706
Rights: Copyright © 2009, American Society for Microbiology. All Rights Reserved.
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/22310

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