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T cells are able to promote lipopolysaccharide-induced bone resorption in mice in the absence of B cells.


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タイトル: T cells are able to promote lipopolysaccharide-induced bone resorption in mice in the absence of B cells.
著者: Yamaguchi, M. / Ukai, Takashi / Kaneko, T. / Yoshinaga, Megumi / Yokoyama, M. / Ozaki, Y. / Hara, Yoshitaka
発行日: 2008年10月
引用: Journal of Periodontal Research, 43(5), pp.549-555; 2008
抄録: Background and Objective: T cells and their cytokines are believed to be key factors in periodontal disease and bone resorption. We previously showed that T cells transferred to nude mice were related to inflammatory bone resorption in vivo. However, it has not been clarified whether T cells can induce bone resorption in the absence of B cells. In this study, we therefore investigated the ability of T cells to induce bone resorption without B cells, using both T cell- and B cell-deficient mice with severe combined immune deficiency (SCID). Material and Methods: Escherichia coli lipopolysaccharide (LPS) was injected into the gingivae of SCID mice reconstituted by T cells (SCID + T mice). Wild-type C.B-17 mice and SCID mice were used as control animals. Alveolar bone resorption and production of cytokines in the gingivae were then compared histopathologically and immunohistologically. Results: The degree of bone resorption in SCID + T mice was significantly greater than that in SCID mice but less than that in wild-type mice. The same tendency was found for expression of receptor activator of nuclear factor kappaB ligand. The number of interferon-gamma-positive cells in SCID + T mice was the highest of the three groups. In contrast, interleukin-4-positive cells were detected in wild-type mice but not in SCID + T and SCID mice. Conclusion: The results suggest that T cells are able to promote LPS-induced bone resorption in the absence of B cells. The expressions of cytokines in the presence of B cells are quite different.
キーワード: T cell / Bone resorption / RANKL / Lipopolysaccharide
URI: http://hdl.handle.net/10069/22315
ISSN: 16000765
DOI: 10.1111/j.1600-0765.2008.01083.x
PubMed ID: 18624940
権利: (c) 2008 Blackwell Munksgaard / The definitive version is available at www.blackwell-synergy.com
資料タイプ: Journal Article
原稿種類: author
出現コレクション:040 学術雑誌論文

引用URI : http://hdl.handle.net/10069/22315

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