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Pathological influence of obesity on renal structural changes in chronic kidney disease.


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タイトル: Pathological influence of obesity on renal structural changes in chronic kidney disease.
著者: Kato, Shigeko / Nazneen, Arifa / Nakashima, Yumiko / Razzaque, Mohammed Shawkat / Nishino, Tomoya / Furusu, Akira / Yorioka, Noriaki / Taguchi, Takashi
発行日: 2009年 8月
出版者: Springer Japan
引用: Clinical and experimental nephrology, 13(4), pp.332-340; 2009
抄録: BACKGROUND: Role of obesity in renal pathological and structural changes remains poorly investigated, and this study was designed to examine the pathological effects of obesity on renal structural components in patients with chronic kidney diseases (CKD). METHODS: The study subjects were obese (body mass index, BMI > or = 25 kg/m2) patients with nonglomerulonephritis (non-GN, n = 26), IgA nephropathy (IgAN, n = 19), benign nephrosclerosis (BNS, n = 15), and thin basement membrane disease (TMD, n = 6), and 65 nonobese controls (n = 20, 20, 10, and 15, respectively). Patients were evaluated for glomerular lesions (mesangial proliferation and focal segmental/global glomerulosclerosis), glomerular size, and thickness of glomerular basement membrane (GBM). RESULTS: Urinary protein was higher in obese non-GN, IgAN, and BNS groups than in the respective controls. Focal segmental glomerulosclerosis (FSGS) lesions were noted in all obesity groups. The glomeruli were larger in size in obese than in nonobese patients of the non-GN and IgAN groups. The glomeruli of nonobese TMD and BNS patients were significantly larger in size than those of nonobese non-GN patients. GBM were thicker in obese than in nonobese patients irrespective of types of glomerular diseases, but only significantly so in non-GN and BNS groups. CONCLUSION: In non-GN, IgAN, and BNS, obesity worsens proteinuria and is associated with structural changes such as glomerulomegaly and GBM thickening, similar to changes observed in obesity-related nephropathy. Obesity seems to worsen the renopathological state in CKD.
キーワード: Chronic kidney disease / Electron microscopy / Glomerular basement membrane / IgA nephropathy / Obesity / Pathology
URI: http://hdl.handle.net/10069/22338
ISSN: 13421751
DOI: 10.1007/s10157-009-0169-3
PubMed ID: 19533267
権利: © Japanese Society of Nephrology 2009 / The original publication is available at www.springerlink.com
資料タイプ: Journal Article
原稿種類: author
出現コレクション:110 学術雑誌論文

引用URI : http://hdl.handle.net/10069/22338

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