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プラジカンテルによる治療後短期間に起こったビルハルツ住血吸虫の再感染


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Title: プラジカンテルによる治療後短期間に起こったビルハルツ住血吸虫の再感染
Other Titles: SCHISTOSOMA HAEMATOBIUM REINFECTION OCCURRED SHORTLY AFTER TREATMENT WITH PRAZIQUANTEL
Authors: 行天, 淳一 / 木村, 英作 / Muhoho, N.D. / 勝又, 達哉 / Migwi, D.K. / Mutua, W.R. / 後藤, 牧人 / 宇賀, 昭二 / 塚本, 増久 / 嶋田, 雅暁 / 青木, 克己
Authors (alternative): Gyoten, Junichi / Kimura, Eisaku / Muhoho, N.D. / Katsumata, Tatsuya / Migwi, D.K. / Mutua, W.R. / Goto, Makito / Tsukamoto, Masuhisa / Uga, Shoji / Shimada, Masaaki / Aoki, Yoshiki
Issue Date: 15-Jun-1992
Publisher: 日本熱帯医学会 / Japanese Society of Tropical Medicine
Citation: 日本熱帯医学会雑誌, vol.20(2), pp.157-164; 1992
Abstract: 今日,住血吸虫症の地域村落に於けるコントロール法としては化学療法が最も効果的であると言われている。しかし,これまで行われたほとんど全てのコントロールプログラムにおいては集団治療後,再感染や重感染が起こり,繰り返し集団治療を行うことが必要となってくる(Wilkins,1989; World Health Organization,1985)。再感染率およびその強さは種々の要因により変化し,各村落により大きく異なっている(Wilkins,1989)。このことから,それぞれの村に於ける再感染の状況を把握し,それに関与する要因を見いだすことは,より効果的な集団治療の方法の研究に大いに役立つものと思われる。著者らはピルハルツ住血吸虫症の対策研究を,ケニア共和国コースト州Kwale地区で行っている。今回Kwale地区のある村でプラジカンテル(PZQ)を用いて選択的集団治療を行い,治療後の住民の感染の変化を1年間にわたり観察した。本研究はこの村に於ける再感染の特徴を把握することを目的として,これまで得られたデータを解析したものである。 / In Mwachinga Village, Kwale district, Kenya, selective mass chemotherapy (SMC) of schistosomiasis haematobium with praziquantel (PZQ) was conducted from July 1986 through August of the same year. "SMC" caused a marked reduction in the overall prevalence (32.6%) and intensity (23.4%) of infection of the pretreatment level three months later. However, prevalence and intensity of infection rose again to 60.9% and 52.7% of their respective levels one year after treatment. Of individuals cured by "PZQ", 30.4% became reinfected with S. haematobium within 1 year. Most of the reinfected individuals were children aged less than 19 years, especially, in the 10-14 years old age bracket. The prevalence of reinfection was two times higher than that in the other children. The reinfection occurred frequently in individuals who showed heavy infection before treatment. The egg counts in reinfected individuals were lower than their pretreatment levels and didn't differ by sex, age nor pretreatment egg count levels. Our previous communication (Shimada et at., 1987, 1989b) had been revealed that children were frequently in contact with infested water and levels of water contact reflected a prevalence and intensity of infection in our study population. The results of the present study were probably again reflected by human water contact in our study area.
URI: http://hdl.handle.net/10069/22404
ISSN: 03042146
Rights: Japanese Society of Tropical Medicine
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/22404

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