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DAILY OBSERVATION OF ANTIBODY LEVELS AMONG DENGUE PATIENTS DETECTED BY ENZYME-LINKED IMMUNOSORBENT ASSAY (ELISA)


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Title: DAILY OBSERVATION OF ANTIBODY LEVELS AMONG DENGUE PATIENTS DETECTED BY ENZYME-LINKED IMMUNOSORBENT ASSAY (ELISA)
Other Titles: デングウイルス感染者におけるELISA抗体価の経日的観察
Authors: Ruechusatsawat, Krangsak / Morita, Kouichi / Tanaka, Mariko / Vongcheree, Suthon / Rojanasuphot, Sunthalee / Warachit, Paijit / Kanai, Kohmi / Thongtradol, Pichai / Nimnakorn, Pisit / Kanungkid, Somyods / Igarashi, Akira
Authors (alternative): Ruechusatsawat, Krangsak / 森田, 公一 / 田中, 真理子 / Vongcheree, Suthon / Rojanasuphot, Sunthalee / Warachit, Paijit / 金井, 興美 / Thongradol, Pichai / Nimnakorn, Pisit / Kanungkid, Somyods / 五十嵐, 章
Issue Date: 15-Mar-1994
Publisher: 日本熱帯医学会 / Japanese Society of Tropical Medicine
Citation: 日本熱帯医学会雑誌, vol.22(1), pp.9-12; 1994
Abstract: Serial serum specimens from forty eight dengue patients admitted to the hospital on day 2, day 3, or day 4 post onset were examined sequencially by enzyme-linked immunosorbent assay for laboratory diagnosis according to the criteria set by Innis et ai. (3) Cumulative ELISA positive rates among forty secondary dengue infection patients were 95 % and 100 % at day 6 and day 7 post onset, respectively while the ELISA positive rates at day 3, day 4, and day 5 were 17.5 %, 37.5 %, and 75 %. Cumulative ELISA positive rates among eight primary dengue patients were 87.5 % and 100 % at day 6 and day 7 post onset, while the rates at day 4, and day 5 were 12.5 % and 50 %. Thus, in order to achieve better diagnostic efficiency according to the criteria, convalescent sera should be taken after the 6th day from the onset of the disease. Four out of 74 secondary infection patients, corresponding to 5 % of the patients, showed poor response of dengue-specific IgM antibody (less than 10 units) even when discharged, indicating that both IgG and IgM examinations are necessary in secondary dengue infection.
URI: http://hdl.handle.net/10069/22412
ISSN: 03042146
Rights: Japanese Society of Tropical Medicine
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/22412

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