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GENOTYPE IDENTIFICATION OF HEPATITIS C VIRUS (HCV) ISOLATED FROM A SINGLE JAPANESE CARRIER IN NAGASAKI PREFECTURE AND GENOME ANALYSIS OF E1 AND E2/NS1 ENVELOPE GLYCOPROTEIN REGIONS


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タイトル: GENOTYPE IDENTIFICATION OF HEPATITIS C VIRUS (HCV) ISOLATED FROM A SINGLE JAPANESE CARRIER IN NAGASAKI PREFECTURE AND GENOME ANALYSIS OF E1 AND E2/NS1 ENVELOPE GLYCOPROTEIN REGIONS
その他のタイトル: 長崎県下1名のC型肝炎(HCV)患者血清中のHCVウイルス遺伝子型別及びE1とE2/NSI糖蛋白質領域の遺伝子解析
著者: Zheng, Wei-Yun
著者(別表記) : 鄭, 薇筠
発行日: 1994年12月15日
出版者: 日本熱帯医学会 / Japanese Society of Tropical Medicine
引用: 日本熱帯医学会雑誌, vol.22(4), pp.169-177; 1994
抄録: The nucleotide (nt) sequence of a Hepatitis C virus genome (HCV-N) which was derived from a single Japanese patient's serum in Nagasaki Prefecture has been determined by multiple clones coverning 22 overlapping regions of the HCV geneme. The sequenced region consisted of 9295 nt, including 248 nt of 5'-untranslated region (UTR), a single large open reading frame (ORF) encoding a polyprotein of 3010 amino acids (aa) and a 17 nt of 3'-UTR. Phylogenetic analysis indicated that HCV-N belongs to II/1b genotype of group 1. Two other Nagasaki HCV strains (HCV-N1 and HCV-N2) were also sequenced in the E1 and N-terminus of the E2/NS1 regions. Two hypervariable regions (HVR1 and HVR2) were found in the N-terminus of E2/NS1 region among 3 Nagasaki strains and 7 other HCV strains with published sequences. Two well-conserved aa sequences were also identified among 10 HCV strains in the E1 and N-terminus of the E2/NS1 regions. The results will be useful for future understanding on the pathogenesis, virological diagnosis and development of vaccine for HCV.
URI: http://hdl.handle.net/10069/22414
ISSN: 03042146
権利: Japanese Society of Tropical Medicine
資料タイプ: Journal Article
原稿種類: publisher
出現コレクション:120 学術雑誌論文

引用URI : http://hdl.handle.net/10069/22414

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