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Clinical significance of serum HMGB-1 and sRAGE levels in systemic sclerosis: association with disease severity.


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Title: Clinical significance of serum HMGB-1 and sRAGE levels in systemic sclerosis: association with disease severity.
Authors: Yoshizaki, Ayumi / Komura, Kazuhiro / Iwata, Yohei / Ogawa, Fumihide / Hara, Toshihide / Muroi, Eiji / Takenaka, Motoi / Shimizu, Kazuhiro / Hasegawa, Minoru / Fujimoto, Manabu / Sato, Shinichi
Issue Date: Mar-2009
Publisher: Springer Netherlands
Citation: Journal of clinical immunology, 29(2), pp.180-189; 2009
Abstract: INTRODUCTION: The high mobility group box 1 protein (HMGB-1)/advanced glycation end products (RAGE) system is recently shown to play an important part in immune/inflammatory disorders. However, the association of this system in systemic sclerosis (SSc) remains unknown. MATERIALS AND METHODS: To determine clinical association of serum levels of HMGB-1 and soluble RAGE (sRAGE) in patients with SSc, sera from 70 patients with SSc and 25 healthy controls were examined by enzyme-linked immunosorbent assay. Sera from tight-skin mice and bleomycin-induced scleroderma mice, animal models for SSc, were also examined. Skin HMGB-1 and RAGE expression was assessed by immunohistochemistry. RESULTS AND DISCUSSION: Serum HMGB-1 and sRAGE levels in SSc were higher than those in controls. Similarly, HMGB-1 and sRAGE levels in animal SSc models were higher than those in control mice. SSc patients with elevated HMGB-1 and sRAGE levels had more frequent involvement of several organs and immunological abnormalities compared to those with normal levels. Furthermore, HMGB-1 and sRAGE levels correlated positively with modified Rodnan total skin thickness score and negatively with pulmonary function test. CONCLUSIONS: HMGB-1 and sRAGE expression in the sclerotic skin was more intense than normal skin. These results suggest that elevated serum HMGB-1 and sRAGE levels are associated with the disease severity and immunological abnormalities in SSc.
Keywords: Autoimmune disease / HMGB-1 / RAGE / Systemic sclerosis / Toll-like receptor
URI: http://hdl.handle.net/10069/22498
ISSN: 02719142
DOI: 10.1007/s10875-008-9252-x
PubMed ID: 18825489
Rights: © Springer Science+Business Media, LLC 2008 / The original publication is available at www.springerlink.com
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/22498

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