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Rapid screening of topoisomerase gene mutations by a novel melting curve analysis method for early warning of fluoroquinolone-resistant Streptococcus pneumoniae emergence.


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Title: Rapid screening of topoisomerase gene mutations by a novel melting curve analysis method for early warning of fluoroquinolone-resistant Streptococcus pneumoniae emergence.
Authors: Fukushima, Kazuko / Hirakata, Yoichi / Sugahara, Kazuyuki / Yanagihara, Katsunori / Kondo, Akira / Kohno, Shigeru / Kamihira, Shimeru
Issue Date: Dec-2006
Publisher: American Society for Microbiology
Citation: Journal of clinical microbiology, 44(12), pp.4553-4558; 2006
Abstract: We developed a real-time PCR assay combined with melting curve analysis for rapidly genotyping quinolone resistance-determining regions (QRDR) of topoisomerase genes in Streptococcus pneumoniae. This assay was not only accurate for the screening of fluoroquinolone (FQ) resistance but also relevant as an early warning system for detecting preexisting single QRDR mutations.
URI: http://hdl.handle.net/10069/22514
ISSN: 00951137
DOI: 10.1128/JCM.01887-06
PubMed ID: 17021062
Rights: Copyright © 2006, American Society for Microbiology. All Rights Reserved.
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/22514

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