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Elevated levels of high mobility group box chromosomal protein-1 (HMGB-1) in sera from patients with severe bacterial pneumonia coinfected with influenza virus.


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Title: Elevated levels of high mobility group box chromosomal protein-1 (HMGB-1) in sera from patients with severe bacterial pneumonia coinfected with influenza virus.
Authors: Kosai, Kosuke / Seki, Masafumi / Yanagihara, Katsunori / Nakamura, Shigeki / Kurihara, Shintaro / Izumikawa, Koichi / Kakeya, Hiroshi / Yamamoto, Yoshihiro / Tashiro, Takayoshi / Kohno, Shigeru
Issue Date: 2008
Publisher: Taylor & Francis
Citation: Scandinavian journal of infectious diseases, 40(4), pp.338-342; 2008
Abstract: Plasma levels of high mobility group box chromosomal protein-1 (HMGB-1), as well as of other inflammatory molecules such as interleukin-6 (IL-6), regulated on activation normal T-cell expressed and secreted (RANTES), and soluble intercellular adhesion molecule-1 (sICAM-1), were determined in patients with bacterial pneumonia coinfected with influenza virus. HMGB-1 levels were significantly elevated in these patients compared to patients undergoing mild bacterial pneumonia alone (p < 0.01). Among cases of coinfection, we found a significant correlation between the concentration of HMGB-1 and white blood cell counts (p < 0.05, r = 0.612). Levels of IL-6 were also higher in these patients than in patients with bacterial pneumonia alone (p < 0.05), despite similar levels of RANTES and sICAM-1 in the 2 groups. These data suggest that HMGB-1 is involved in the pathogenesis of severe bacterial pneumonia coinfected with influenza virus.
Keywords: HMGB-1 / influenza virus / bacterial pneumonia / co-infection
URI: http://hdl.handle.net/10069/22523
ISSN: 00365548
DOI: 10.1080/00365540701660486
PubMed ID: 17918013
Rights: © 2008 Informa UK Ltd. (lnforma Healthcare, Thylor & Francis As) / This is an electronic version of an article published in Scandinavian journal of infectious diseases, 40(4), pp.338-342; 2008. Scandinavian Journal of Infectious Diseases is available online at: http://www.informaworld.comopenurl?genre=article&issn=0036-5548&volume=40&issue=4&spage=338.
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/22523

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