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Immunopathogenesis of Pelvic Endometriosis: Role of Hepatocyte Growth Factor, Macrophages and Ovarian Steroids


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Title: Immunopathogenesis of Pelvic Endometriosis: Role of Hepatocyte Growth Factor, Macrophages and Ovarian Steroids
Authors: Khan, Khaleque Newaz / Kitajima, Michio / Hiraki, Koichi / Fujishita, Akira / Sekine, Ichiro / Ishimaru, Tadayuki / Masuzaki, Hideaki
Issue Date: Nov-2008
Publisher: Blackwell Publishing
Citation: American Journal of Reproductive Immunology, 60(5), pp.383-404; 2008
Abstract: Endometriosis, a chronic disease characterized by endometrial tissue located outside of the uterine cavity and is associated with chronic pelvic pain and infertility. However, an in-depth understanding of the pathophysiology of endometriosis is still elusive. It is generally believed that besides ovarian steroid hormones, the growth of endometriosis can be regulated by innate immune system in pelvic microenvironment by their interaction with endometrial cells and immune cells. We conducted a series of studies in perspectives of pelvic inflammation that is triggered primarily by bacterial endotoxin (lipopolysacccharide, LPS) and is mediated by toll-like receptor 4 (TLR4) and showed their involvement in the development of pelvic endometriosis. As a cellular component of innate immune system, macrophages were found to play a central role in inducing pelvic inflammatory reaction. We further reported here that peritoneal macrophages retain receptors encoding for estrogen and progesterone and ovarian steroids also participate in producing an inflammatory response in pelvic cavity and involved in the growth of endometriosis either alone or in combination with hepatocyte growth factor (HGF). As a pleiotropic growth factor, HGF retains multifunctional role in endometriosis. We describe here the individual and step-wise role of HGF, macrophages and ovarian steroid hormones and their orchestrated involvement in the immunopathogenesis of pelvic endometriosis.
Keywords: pelvic endometriosis / hepatocyte growth factor / macrophages / toll-like receptor 4 / ovarian steroids / inflammation
URI: http://hdl.handle.net/10069/22528
ISSN: 10467408
DOI: 10.1111/j.1600-0897.2008.00643.x
Rights: © 2008 Blackwell Munksgaard / The definitive version is available at www.blackwell-synergy.com
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/22528

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