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Infliximab is Effective for Takayasu Arteritis Refractory to Glucocorticoid and Methotrexate


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Title: Infliximab is Effective for Takayasu Arteritis Refractory to Glucocorticoid and Methotrexate
Authors: Tanaka, Fumiko / Kawakami, Atsushi / Iwanaga, Nozomi / Tamai, Mami / Izumi, Yasumori / Aratake, Kouichiro / Arima, Kazuhiko / Kamachi, Makoto / Nakamura, Hideki / Huang, Mingguo / Ida, Hiroaki / Origuchi, Tomoki / Eguchi, Katsumi
Issue Date: Apr-2006
Publisher: 日本内科学会 / The Japanese Society of Internal Medicine
Citation: Internal Medicine, vol.45(5), pp.313-316; 2006
Abstract: We have experienced a Takayasu arteritis (TA) patient, successfully treated with infliximab, who did not respond well to conventional therapy with glucocosteroid and methotrexate. Takayasu arteritis had developed in a 24yearold woman (March 2003) who had been treated with glucocorticoid including methylprednisolone pulse therapy and methotrexate; however, she relapsed during the tapering of the dosage of oral prednisolone. Nineteen months after the first administration of glucocorticoid, 3 mg/kg of infliximab was introduced to the patient. The therapeutic efficacy of infliximab was markedly demonstrated; the patient's Creactive protein (CRP) value returned to almost normal range with subsequent tapering of the dosage of oral prednisolone in the absence of further relapse. This is the first case presentation of TA in Japan successfully treated with infliximab.
Keywords: Takayasu arteritis / infliximab
URI: http://hdl.handle.net/10069/22554
ISSN: 09182918
DOI: 10.2169/internalmedicine.45.1377
Rights: Copyright (c) 2006 (社)日本内科学会
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/22554

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