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Clinical Comparative Study of Sulbactam/Ampicillin and Imipenem/Cilastatin in Elderly Patients with Community-Acquired Pneumonia


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Title: Clinical Comparative Study of Sulbactam/Ampicillin and Imipenem/Cilastatin in Elderly Patients with Community-Acquired Pneumonia
Authors: Yanagihara, Katsunori / Fukuda, Yuichi / Seki, Masafumi / Izumikawa, Koichi / Higashiyama, Yasuhito / Miyazaki, Yoshitsugu / Hirakata, Yoichi / Tomono, Kazunori / Mizuta, Yohei / Tsukamoto, Kazuhiro / Kohno, Shigeru
Issue Date: Oct-2006
Publisher: 日本内科学会 / The Japanese Society of Internal Medicine
Citation: Internal Medicine, vol.45(17), pp.995-999; 2006
Abstract: Objective: To evaluate the clinical usefulness of sulbactam/ampicillin therapy for community-acquired pneumonia in the elderly. Methodology: A randomized prospective clinical study was conducted in the elderly patients with moderate-to-severe community-acquired bacterial pneumonia. Results: Overall clinical efficacy of sulbactam/ampicillin therapy (6 g/day) in these patients (efficacy rate: 91.4%) was comparable to that of imipenem/cilastatin therapy (1 g/day; efficacy rate: 87.5%), when each therapy was administered intravenously twice daily for 7-14 days. With regard to clinical efficacy based on disease severity, bacteriological efficacy, improvement of chest X-ray findings and adverse reactions, the two therapies were comparable. Conclusion: These results suggest that sulbactam/ampicillin therapy has excellent efficacy and tolerability and that it may be highly effective, even in severe cases of pneumonia. This regimen may thus serve as first-line treatment for the treatment of community-acquired pneumonia in elderly patients.
Keywords: community-acquired pneumonia / pulmonary infection / clinical trial / elderly patients / antibiotics
URI: http://hdl.handle.net/10069/22559
ISSN: 09182918
DOI: 10.2169/internalmedicine.45.1717
Rights: Copyright (c) 2006 (社)日本内科学会
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/22559

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