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Severe Legionnaires' Disease Successfully Treated Using a Combination of Fluoroquinolone, Erythromycin, Corticosteroid, and Sivelestat


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Title: Severe Legionnaires' Disease Successfully Treated Using a Combination of Fluoroquinolone, Erythromycin, Corticosteroid, and Sivelestat
Authors: Kakeya, Hiroshi / Ehara, Naomi / Fukushima, Kiyoyasu / Seki, Masafumi / Izumikawa, Koichi / Yamamoto, Yoshihiro / Yanagihara, Katsunori / Saito, Atsushi / Kohno, Shigeru
Issue Date: Apr-2008
Publisher: 日本内科学会 / The Japanese Society of Internal Medicine
Citation: Internal Medicine, vol.47(8), pp.773-777; 2008
Abstract: The patient was a 67-year-old man with diabetes mellitus who had been to a hot spring spa a few days before his admission. The diagnosis of Legionella pneumonia was made using a urinary antigen assay. Intravenous pazufloxacin and oral clarithromycin were started. However, despite these treatments, he developed acute respiratory distress syndrome (ARDS). He was administered the combination of intravenous pazufloxacin and erythromycin, corticosteroid, and sivelestat for two weeks. Then he was successfully recovered. The outcome suggests that treatment with corticosteroid and sivelestat, in addition to a combination of appropriate anti-Legionella antibiotics, should be considered for patients with severe Legionella pneumonia with ARDS.
Keywords: severe Legionella pneumonia / fluoroquinolone / erythromycin / corticosteroid / sivelestat
URI: http://hdl.handle.net/10069/22577
ISSN: 09182918
DOI: 10.2169/internalmedicine.47.0677
Rights: Copyright (c) 2008 (社)日本内科学会
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/22577

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