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A Clinical Comparative Study of Piperacillin and Sulbactam/Ampicillin in Patients with Community-Acquired Bacterial Pneumonia


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Title: A Clinical Comparative Study of Piperacillin and Sulbactam/Ampicillin in Patients with Community-Acquired Bacterial Pneumonia
Authors: Seki, Masafumi / Higashiyama, Yasuhito / Imamura, Yoshifumi / Nakamura, Shigeki / Kurihara, Shintaro / Izumikawa, Koichi / Kakeya, Hiroshi / Yamamoto, Yoshihiro / Yanagihara, Katsunori / Tashiro, Takayoshi / Kohno, Shigeru
Issue Date: Jan-2009
Publisher: 日本内科学会 / The Japanese Society of Internal Medicine
Citation: Internal Medicine, 48(1), pp.49-55; 2009
Abstract: Objective To evaluate the clinical usefulness of piperacillin (4 g/day) therapy for community-acquired pneumonia compared to sulbactam/ampicillin (6 g/day). Methods A randomized prospective clinical study was conducted in patients with mild to severe community-acquired bacterial pneumonia. Results The overall clinical efficiency of piperacillin therapy (4 g/day) in these patients (41/53=77.4%) was comparable to that of sulbactam/ampicillin therapy (6 g/day: efficiency rate: 33/49=67.3%), when each therapy was administered intravenously for 3-7 days. With regards to clinical efficiency based on disease severity, bacteriological efficiency, improvement in chest X-ray findings and adverse reactions, the two therapies were comparable, even though we found more efficiency for patients who had underlying diseases and there were also cost benefits in piperacillin therapy, compared with sulbactam/ampicillin therapy Conclusion The results suggested that piperacillin therapy has good efficiency and tolerability and that it may be highly effective, even in cases of pneumonia with underlying diseases. This regimen may thus serve as a first line treatment of community-acquired pneumonia.
Keywords: community-acquired pneumonia / antibiotics / clinical trials / pulmonary infections
URI: http://hdl.handle.net/10069/22584
ISSN: 09182918
DOI: 10.2169/internalmedicine.48.1614
Rights: Copyright (c) 2009 (社)日本内科学会
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/22584

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