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The Significance of Enzyme Immunoassay for the Assessment of Hepatitis B Virus Core-Related Antigen following Liver Transplantation


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Title: The Significance of Enzyme Immunoassay for the Assessment of Hepatitis B Virus Core-Related Antigen following Liver Transplantation
Authors: Fujimoto, Masumi / Ichikawa, Tatsuki / Nakao, Kazuhiko / Miyaaki, Hisamitsu / Shibata, Hidetaka / Eguchi, Susumu / Takatsuki, Mitsuhisa / Nagaoka, Shinya / Yatsuhashi, Hiroshi / Kanematsu, Takashi / Eguchi, Katsumi
Issue Date: Sep-2009
Publisher: 日本内科学会 / The Japanese Society of Internal Medicine
Citation: Internal Medicine, vol.48(18), pp.1577-1583; 2009
Abstract: Purpose Recently, a new enzyme immunoassay for the detection of hepatitis B virus (HBV) core-related antigen (HBcrAg) has been reported. In this study, we proposed to account for feasibility of HBcrAg assay, and discuss the dynamics of HBV seen in patients following HBV-related living donor liver transplantation (LDLT). Methods and results This study involved 12 patients; 11 patients had positive serum HBcrAg, and 6 patients had negative HBV-DNA. In the post-operation period, all cases were negative for HBV-DNA and HBsAg in sera under prophylaxis therapy. At post-operation, 5 of the 12 had positive serum HBcrAg, and at stable state, 6 had positive serum HBcrAg postoperatively. The mean levels of HBcrAg following LDLT were significantly lower than those seen in the preoperative-operation stage. Conclusion This enzyme immunoassay is a readily utilizable marker of HBV replication in the post transplantation stage. Furthermore, the evaluation of HBV activity by HBcrAg assay must be studied to determine the appropriate prophylaxis for controlling replication of HBV following LDLT.
Keywords: hepatitis B virus / liver transplantation / hepatitis B virus core-related antigen
URI: http://hdl.handle.net/10069/22589
ISSN: 09182918
DOI: 10.2169/internalmedicine.48.2000
Rights: Copyright (c) 2009 (社)日本内科学会
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/22589

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