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Effect of minodronic acid hydrate on hip geometry in Japanese women with postmenopausal osteoporosis.


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Title: Effect of minodronic acid hydrate on hip geometry in Japanese women with postmenopausal osteoporosis.
Authors: Ito, Masako / Sone, Teruki / Fukunaga, Masao
Issue Date: May-2010
Publisher: Springer Japan
Citation: Journal of bone and mineral metabolism, 28(3), pp.334-341; 2010
Abstract: Dual-energy X-ray absorptiometry-based hip structural analysis was performed to evaluate the effect of a bisphosphonate, minodronic acid hydrate, on the geometry of the proximal femur in Japanese patients with osteoporosis. The subjects were 103 postmenopausal patients (average age 63.9 +/- 6.4 years) with primary osteoporosis. Minodronic acid hydrate was administered orally at a dose of 1 mg/day for 12 months. Significant early responses at 3-6 months after the start of administration were observed in all three regions of the proximal femur (narrow neck, intertrochanter, and shaft) in terms of bone density, geometry, and bone strength indices. The outcomes of therapy included a reduction of the internal diameter of the cortical bone (-0.1, -0.6, and -0.2% in the neck, intertrochanter, and shaft, respectively, at 12 months; not significant) and a significant increase in cortical thickness (3.1, 3.7, and 2.0% in the respective regions at 12 months). Furthermore, minodronic acid hydrate induced a significant enlargement of the cross-sectional bone area, which is related to compressive strength; a significant increase in cross-sectional moment of inertia and section modulus (SM 4.9, 5.8, and 2.9% in the neck, intertrochanter, and shaft, respectively, at 12 months; P < 0.001), which are related to the bending strength; and a significant reduction in buckling ratio (BR -3.0% (P < 0.001), -4.2% (P < 0.001), and -1.4% (P < 0.05) in the respective regions at 12 months), which reflects improved cortical stability. These findings show that minodronic acid hydrate reduces age-related endocortical bone resorption, leading to increased cortical thickness and sustained or enhanced bone strength.
Keywords: Bisphosphonate / Hip geometry / Minodronic acid hydrate / Osteoporosis
URI: http://hdl.handle.net/10069/22649
ISSN: 09148779
DOI: 10.1007/s00774-009-0138-7
PubMed ID: 19937358
Rights: © The Japanese Society for Bone and Mineral Research and Springer 2009 / The original publication is available at www.springerlink.com
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/22649

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