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Clinicopathological features of "intraductal papillary neoplasm of the bile duct" and patient outcome after surgical resection.


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Title: Clinicopathological features of "intraductal papillary neoplasm of the bile duct" and patient outcome after surgical resection.
Authors: Nanashima, Atsushi / Kinoshita, Naoe / Nakanuma, Yasuni / Zen, Yoh / Sumida, Yorihisa / Abo, Takafumi / Hidaka, Shigekazu / Takeshita, Hiroaki / Yasutake, Toru / Hayashi, Tomayoshi / Nagayasu, Takeshi
Issue Date: Jul-2008
Publisher: Thieme
Citation: Hepato-gastroenterology, 55(85), pp.1167-1173; 2008
Abstract: BACKGROUND/AIMS: Intraductal papillary neoplasm of the bile duct (IPNB) represents a biliary papillary tumor mainly growing in the bile duct lumen resembling intraductal papillary mucin-producing neoplasm of the pancreas. However, its clinical spectrum and characteristics have not been fully evaluated. METHODOLOGY: To define the clinicopathologic characteristics and prognosis of IPNB patients, 6 cases of IPNB who underwent surgical resection are presented. RESULTS: Patients were 3 males and 3 females, aged between 47 and 79 years. Five patients had histories of hepatobiliary disease. Imagery showed cystic or diffuse dilatation of the bile ducts. Tumor markers were not valuable for diagnosis. All patients underwent hemihepatectomy with or without resection of the caudate lobe or extrahepatic bile duct. Examination showed polypoid tumors in 5 cases though 1 case had no evident tumor. Mucin was observed in 3 cases. Five cases were well-differentiated adenocarcinoma and 1 had poorly differentiated adenocarcinoma. Vascular invasion was rare and lymph node metastasis was not observed. In-situ spread of carcinoma was seen along biliary mucosa in 3 cases. Five cases survived without tumor relapse for long periods but 1 died of tumor recurrence at 31 months. CONCLUSIONS: Complete resection of IPNB based on accurate preoperative assessment of tumor extension provides a good prognosis.
Keywords: intraductal papillary neoplasm / liver / dilated bile duct / hepatectomy / good prognosis
URI: http://hdl.handle.net/10069/22651
ISSN: 01726390
PubMed ID: 18795651
Rights: Copyright 2008 Thieme Publishing
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/22651

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