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Autoantibody against caspase-3, an executioner of apoptosis, in patients with systemic sclerosis.


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Title: Autoantibody against caspase-3, an executioner of apoptosis, in patients with systemic sclerosis.
Authors: Okazaki, Shihoko / Ogawa, Fumihide / Iwata, Yohei / Hara, Toshihide / Muroi, Eiji / Komura, Kazuhiro / Takenaka, Motoi / Shimizu, Kazuhiro / Hasegawa, Minoru / Fujimoto, Manabu / Sato, Shinichi
Issue Date: May-2010
Publisher: Springer Berlin
Citation: Rheumatology international, 30(7), pp.871-878; 2010
Abstract: The objective of the study was to determine the presence or levels of antibodies (Abs) against caspase-3 and their clinical relevance in systemic sclerosis (SSc). Anti-caspase-3 Ab was examined by enzyme-linked immunosorbent assay and immunoblotting. IgG anti-caspase-3 Ab levels in SSc patients were higher than in normal controls. SSc patients positive for IgG anti-caspase-3 Ab had significantly longer disease duration, more frequent presence of decreased %VC and %DLco, and elevated levels of serum immunoglobulin and erythrocyte sedimentation rates. IgG anti-caspase-3 Ab levels correlated positively with serum IgG levels, renal vascular resistance, and serum levels of 8-isoprostane. Immunoblotting analysis confirmed the presence of anti-caspase-3 Ab in sera from SSc patients. Caspase-3 enzymatic activity was inhibited by IgG isolated from SSc sera containing IgG anti-caspase-3 Ab. These results suggest that autoantibody against caspase-3 is generated in SSc and that this Ab is related to the severity of pulmonary fibrosis, vascular damage, and inflammation.
Keywords: Autoantibody / Caspase-3 / Pulmonary fibrosis / Renal vascular damage / Systemic sclerosis
URI: http://hdl.handle.net/10069/22660
ISSN: 01728172
DOI: 10.1007/s00296-009-1068-3
PubMed ID: 19639321
Rights: © Springer-Verlag 2009 / The original publication is available at www.springerlink.com
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/22660

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