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Examination of Rat Carotid Artery Models with Twice-Induced Arterial Balloon Injuries: Observation of Intimal Hyperplasia, Focusing on the Transformation of Vascular Smooth Muscle Tissue


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タイトル: Examination of Rat Carotid Artery Models with Twice-Induced Arterial Balloon Injuries: Observation of Intimal Hyperplasia, Focusing on the Transformation of Vascular Smooth Muscle Tissue
著者: Yoshioka, Tsutomu / Kitagawa, Naoki / Hayashi, Kentaro / Nagata, Izumi
発行日: 2009年12月
出版者: Nagasaki University School of Medicine
引用: Acta medica Nagasakiensia, 54(2), pp.29-32 ; 2009
抄録: We induced arterial balloon injuries twice via a hyperdiastolic balloon catheter inserted into the carotid artery ofWister rats in order to observe the changes in the intima and the media. The thickness of the intima reached a maximum by 14 days after the injury. In a comparison of the thickness of the intima with samples having a once-induced arterial balloon injury, the samples with twice-induced arterial balloon injuries were found to have thickened more significantly. When the proliferating cells of the intima were observed, many proliferative smooth muscle cells were found. In themodels of the twice-induced arterial balloon injuries, the area of the media decreased, while the area of the intima increased. In the models of the twice-induced arterial balloon injuries, intimal hyperplasia with positive remodeling1 was observed, and findings were obtained that were substantially similar to lesions due to either intimal hyperplasia of arteriosclerosis lesions or intimal hyperplasia of restenotic lesions after PTA or stent placement.
キーワード: Twice - induced arterial balloon injuries / Transformation of vascular smooth muscle / Intimal hyperplasia
URI: http://hdl.handle.net/10069/22685
ISSN: 00016055
関連リンク : http://joi.jlc.jst.go.jp/JST.JSTAGE/amn/54.29
資料タイプ: Departmental Bulletin Paper
原稿種類: publisher
出現コレクション:Volume 54, No. 2

引用URI : http://hdl.handle.net/10069/22685

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