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Topical application of 5-fluorouracil on attic cholesteatoma results in downregulation of keratinocyte growth factor and reduction of proliferative activity.


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タイトル: Topical application of 5-fluorouracil on attic cholesteatoma results in downregulation of keratinocyte growth factor and reduction of proliferative activity.
著者: Yamamoto-Fukuda, Tomomi / Terakado, Mariko / Hishikawa, Yoshitaka / Koji, Takehiko / Takahashi, Haruo
発行日: 2008年10月
出版者: Springer Berlin
引用: European archives of oto-rhino-laryngology, 265(10), pp.1173-1178; 2008
抄録: To investigate the cell-biological effect of topically applied 5-fluorouracil (5-FU) on middle ear cholesteatoma, 12 attic cholesteatomas were treated with topical application of 5-FU cream, two to five times with an interval of 2 weeks (5-FU group). The control group comprised 65 cholesteatoma that were not treated with 5-FU. All lesions were later excised surgically and processed for immunohistochemical analyses of Ki-67, keratinocyte growth factor (KGF) and its receptor (KGFR). 5-FU significantly reduced the expression of KGF, did not change KGFR expression, and significantly reduced the Ki-67 labeling index, relative to the control group. The effect of 5-FU on cholesteatoma seems to be mediated, at least in part, through downregulation of KGF in stromal cells and reduction of the proliferative activity of epithelial cells.
キーワード: 5-Fluorouracil / Cholesteatoma / Immunohistochemistry / Keratinocyte growth factor / Ki-67
URI: http://hdl.handle.net/10069/22771
ISSN: 09374477
DOI: 10.1007/s00405-008-0597-9
PubMed ID: 18246360
権利: © Springer-Verlag 2008 / The original publication is available at www.springerlink.com
資料タイプ: Journal Article
原稿種類: author
出現コレクション:110 学術雑誌論文

引用URI : http://hdl.handle.net/10069/22771

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