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Involvement of gaseous low molecular monoxides in the cutaneous reverse passive Arthus reaction: cytoprotective action of carbon monoxide.


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Title: Involvement of gaseous low molecular monoxides in the cutaneous reverse passive Arthus reaction: cytoprotective action of carbon monoxide.
Authors: Shimizu, Kazuhiro / Bae, S J / Hara, Takeshi / Iwata, Y / Yamaoka, T / Komura, Kazuhiro / Muroi, Eiji / Takenaka, Motoi / Ogawa, Fumihide / Sato, Shinichi
Issue Date: Aug-2008
Publisher: Blackwell Publishing Inc.
Citation: Clinical and experimental immunology, 153(2), pp.245-257; 2008
Abstract: The deposition of immune complexes (IC) induces an acute inflammatory response with tissue injury, for which the involvement of nitric oxide (NO) and carbon monoxide (CO) has been suggested. NO is induced by NO synthase (NOS) and CO is generated by haeme oxygenase (HO). Among HO isoenzymes, HO-1 is an induced type. To assess the role of NO and CO in the pathogenic process, the cutaneous reverse passive Arthus reaction was examined using NOS inhibitor, HO-1 stimulator and HO-1 inhibitor. To evaluate the reaction we considered oedema, tumour necrosis factor-alpha, interleukin-6, and neutrophil number. The values of these four parameters were significantly reduced in mice treated with HO-1 stimulator as compared with the positive control mice. Quite the reverse was observed in mice treated with HO-1 inhibitor. These results suggest that the HO-1/CO signalling pathway is a therapeutic target for human IC-mediated disease.
Keywords: Arthus reaction / Carbon monoxide / Haeme oxygenase-1 / Nitric oxide
URI: http://hdl.handle.net/10069/22893
ISSN: 00099104
DOI: 10.1111/j.1365-2249.2008.03688.x
PubMed ID: 18505425
Rights: Journal Compilation © 2008 British Society for Immunology / The definitive version is available at www.blackwell-synergy.com
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/22893

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