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Humoral immune response to islet autoantigens in Japanese patients with type 1 diabetes.


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Title: Humoral immune response to islet autoantigens in Japanese patients with type 1 diabetes.
Authors: Kawasaki, Eiji / Kuriya, Genpei / Satoh, Tsuyoshi / Fujishima, Keiichiro / Moriuchi, Akie / Fukushima, Keiko / Ozaki, Masako / Abiru, Norio / Yamasaki, Hironori / Eguchi, Katsumi
Issue Date: Dec-2008
Publisher: New York Academy of Sciences
Citation: Annals of the New York Academy of Sciences, 1150, pp.248-251; 2008
Abstract: In this study, we evaluated autoantibodies to IA-2 (IA-2As), glutamic acid decarboxylase 65 (GADAs), and islet cell antibodies (ICAs) in 233 patients with type 1 diabetes (M:F = 90:143, mean duration 4.0 +/- 6.7 yr) as a cross-sectional study. Of 233 patients with type 1 diabetes, IA-2A was detected in 58% of patients with duration within 2 weeks, 61% of patients with duration <1 yr, 41% of patients with diabetes for 1-3 yr, 29% for 4-9 yr, and 21% for >or=10 yr. These prevalences were similar to those of ICA, while the prevalence of GADA was not influenced by duration of diabetes with positivity of 63-74%. Thus, as the duration of diabetes became longer, the frequency of GADA(+)/IA-2A(-) patients increased and the frequency of GADA(+)/IA-2A(+) patients decreased. However, the frequency of GADA(-)/IA-2A(+) patients was not influenced by duration of diabetes. The prevalence of IA-2A was significantly higher in abrupt-onset group (68%, n= 79) compared to the slowly progressive group (23%, n= 22) in new-onset patients (P= 0.0001). However, there was no difference in the IA-2A frequency between these two groups (abrupt-onset 26%, n= 53 vs. slowly progressive 24%, n= 21) in patients with long-standing disease, suggesting that IA-2A positivity might persist in patients with slowly progressive type 1 diabetes. These results emphasize the heterogeneity of humoral autoimmunity to protein tyrosine phosphatase-like molecules, but not to GAD, in patients with type 1 diabetes.
Keywords: GAD / IA-2 / ICA
URI: http://hdl.handle.net/10069/22894
ISSN: 00778923
DOI: 10.1196/annals.1447.027
PubMed ID: 19120305
Rights: © 2008 The New York Academy of Sciences
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/22894

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