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Enhanced initial cell responses to chemically modified anodized titanium.


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Title: Enhanced initial cell responses to chemically modified anodized titanium.
Authors: Jimbo, Ryo / Sawase, Takashi / Baba, Koumei / Kurogi, Tadafumi / Shibata, Yasuaki / Atsuta, Mitsuru
Issue Date: Mar-2008
Publisher: Blackwell Publishing
Citation: Clinical implant dentistry and related research, 10(1), pp.55-61; 2008
Abstract: BACKGROUND: Previously, we reported that anodized porous titanium implants have photocatalytic hydrophilicity. However, this effect was not always sufficient for the significant improvement of bone apposition. PURPOSE: The purpose of this study was to improve the photocatalytic properties of porous titanium implants by the fluoride modification of the anodized titanium dioxide (TiO(2)), and to investigate the initial cell response to it. MATERIALS AND METHODS: The ideal concentration of ammonium hydrogen fluoride (NH(4)F-HF(2)) used in this study was determined by a static water contact angle assay. The ideal concentration of NH(4)F-HF(2) was 0.175%, and experimental disks were treated with this concentration. A pluripotent mesenchymal cell line, C2C12, was cultured on the disks in order to investigate cell attachment, morphology, and proliferation. RESULTS: Cell attachment after 30 minutes of culturing was significantly higher for the ultraviolet-irradiated, fluoride-modified anodized TiO(2) (p < .05), and the simultaneous scanning electron microscope observation showed a rather flattened and extended cell morphology. The proliferation rate after 24 hours was also significantly higher for the fluoride-modified anodized TiO(2). CONCLUSION: Fluoride chemical modification enhances the hydrophilic property of the anodized TiO(2) and improves the initial cell response to it.
Keywords: Ammonium hydrogen fluoride / Anodization / Hydrophilicity / Titanium / Ultraviolet irradiation
URI: http://hdl.handle.net/10069/22956
ISSN: 15230899
DOI: 10.1111/j.1708-8208.2007.00061.x
PubMed ID: 18254741
Rights: © 2007, Copyright the Authors / Journal Compilation © 2007, Blackwell Publishing
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/22956

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