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Multicentric occurrence and spread of hepatocellular carcinoma in whole explanted end-stage liver.


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Title: Multicentric occurrence and spread of hepatocellular carcinoma in whole explanted end-stage liver.
Authors: Hidaka, Masaaki / Eguchi, Susumu / Okudaira, Sadayuki / Takatsuki, Mitsuhisa / Tokai, Hirotaka / Soyama, Akihiko / Nagayoshi, Shigeki / Mochizuki, Satoshi / Hamasaki, Koji / Tajima, Yoshitsugu / Kanematsu, Takashi
Issue Date: Feb-2009
Citation: Hepatology research, 39(2), pp.143-148; 2009
Abstract: Aim: Hepatocellular carcinoma (HCC) arising from the end stages of liver cirrhosis is a fair indication for liver transplantation (LT). To pathologically investigate the multicentric occurrence of relatively early staged HCC in cirrhosis, we studied whole explanted livers. Methods: Fourteen explanted livers from patients undergoing living donor LT (LDLT) were examined. The stage of the HCCs was judged to be within the Milan criteria (M-C; a single HCC less than 5 cm or three HCCs less than 3 cm). Histological examination was performed using serially sectioned specimens 5-7 mm in width. Characterization of preoperatively detectable and undetectable lesions was also performed. Results: In nine patients (64.3%), a total of 34 nodules were found after whole liver histological examination (WLHE). In five patients (31%), the results exceeded the M-C. The characteristics of undetectable HCCs included a minute (median size 6 mm), well-differentiated appearance (80%), with indistinct margins (85.3%) and without vascular invasion (94%). There was no recurrence in any patients at the time of follow up (median follow-up period, 30.1 months). Conclusion: A multicentric occurrence of HCCs was demonstrated in cirrhotic livers with HCCs within the M-C. Undetectable HCCs in cirrhotic livers may have no impact on recurrence after LT.
Keywords: Hepatocellular carcinoma / Liver transplantation / Milan criteria / Whole explanted liver
URI: http://hdl.handle.net/10069/23054
ISSN: 13866346
DOI: 10.1111/j.1872-034X.2008.00443.x
PubMed ID: 19054149
Rights: Author Posting. © 2010 The Japan Society of Hepatology. This is the author's version of the work. It is posted here by permission of The Japan Society of Hepatology for personal use, not for redistribution. The definitive version was published in Hepatology research, 39(2), pp.143-148. http://dx.doi.org/10.1111/j.1872-034X.2008.00443.x
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/23054

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