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Regeneration of Graft Livers and Limited Contribution of Extrahepatic Cells After Partial Liver Transplantation in Humans.

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Title: Regeneration of Graft Livers and Limited Contribution of Extrahepatic Cells After Partial Liver Transplantation in Humans.
Authors: Eguchi, Susumu / Takatsuki, Mitsuhisa / Yamanouchi, Kosho / Kamohara, Yukio / Tajima, Yoshitsugu / Kanematsu, Takashi
Issue Date: Mar-2010
Publisher: Springer Netherlands
Citation: Digestive diseases and sciences, 55(3), pp.820-825; 2010
Abstract: Background Liver regeneration is still not fully understood. Partial liver transplantation (LT) can provide the opportunity to investigate the mechanisms of liver regeneration, including the contribution of extrahepatic cells to liver regeneration. Methods Of 61 patients transplanted with partial liver graft between August 1997 and October 2006, 56 patients were studied, including 49 adults and 7 children. Sequential computed tomography volumetric analysis was performed for volume measurement, while proliferating cell nuclear antigen (PCNA) labeling index was investigated for liver cell proliferation in nonprotocol liver biopsy specimens. In addition, 15 male recipients who had female liver grafts were investigated in order to detect Y chromosomes as extrahepatic cells in nonprotocol liver biopsy specimens. Results Graft volume per standard liver volume was markedly increased after adult-to-adult living-donor (LD) LT. In pediatric transplants, there was no volume increase over time. PCNA labeling index was vigorous in adult-to-adult LDLT in the early period after LDLT. No Y chromosome was evident in hepatocytes from female-donor male-recipient grafts during or after liver regeneration. However, in the cases of failing grafts of this type, many Y-chromosome-positive cells were observed in the graft liver. The character of those cells was CD34(-), CK9(-), hepatocyte-specific antigen(-), and CD68(+/-). Conclusion In adult-to-adult LDLT, vigorous liver regeneration occurs in the graft liver, demonstrated by not only volumetric but cell kinetic analysis. Involvement of extrahepatic cells in normal liver regeneration seems limited.
Keywords: Extrahepatic cells / Liver regeneration / Living-donor liver transplantation
URI: http://hdl.handle.net/10069/23064
ISSN: 01632116
DOI: 10.1007/s10620-009-0777-5
PubMed ID: 19296219
Rights: © 2009 The Author(s). This article is published with open access at Springerlink.com / The original publication is available at www.springerlink.com
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/23064

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