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Clinical Significance of Measuring Urinary Sulfated Bile Acids in Adult Patients with Hepatobiliary Diseases.

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タイトル: Clinical Significance of Measuring Urinary Sulfated Bile Acids in Adult Patients with Hepatobiliary Diseases.
著者: Nanashima, Atsushi / Obatake, Masayuki / Sumida, Yorihisa / Abo, Takafumi / Yamane, Yusuke / Nomura, Masahito / Inamura, Yukio / Sawai, Terumitsu / Takeshita, Hiroaki / Hidaka, Shigekazu / Yasutake, Toru / Nagayasu, Takeshi
発行日: 2009年 3月
出版者: Thieme
引用: Hepato-Gastroenterology, 56(90), pp.299-302; 2009
抄録: Background/Aims: Measurement of urinary sulfated bile acid (USBA) level is a simple urine test that reflects the degree of cholestasis in newborns. The aim of this study was to clarify the clinical significances of this test for liver diseases in adults. Methodology: We examined the relationship between USBA level in a urine sample by enzymatic assay and clinical parameters and postoperative complications in 27 patients with hepatobiliary diseases who underwent surgical procedures between 2002 and 2007. Results: Mean USBA in all patients before surgery was 39.8 ± 64.0 μmol/L (median value was 6.6). USBA level was increased in patients with cholestasis. USBA level was significantly correlated with serum total bile acid, total bilirubin level and serum hyaluronic acid level (r=0.850, 0.602 and 0.504, respectively) (p<0.05) and, furthermore, tended to be correlated with liver-uptake ratio (LHL15) by technetium-99m galactosyl human serum albumin (99mTc-GSA) scintigraphy and alanine aminotransferase level (r=-0.469 and 0.436, respectively but not significant). USBA level tended to be associated with postoperative uncontrolled ascites (p=0.050, not significant). Postoperative USBA level by day 7 was not changed; however, USBA level in patients with cholestatic diseases was decreased Conclusions: USBA is a simple and sensitive noninvasive test for cholestasis and also useful to predict postoperative uncontrolled ascites after hepatic resections.
キーワード: Urinary sulfated bile acid / Cholestasis / Hepatectomy / Ascites
URI: http://hdl.handle.net/10069/23097
ISSN: 01726390
PubMed ID: 19579586
関連リンク : http://www.iasg.org/
権利: © H.G.E. Update Medical Publishing.
資料タイプ: Journal Article
原稿種類: author
出現コレクション:030 学術雑誌論文

引用URI : http://hdl.handle.net/10069/23097



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