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Genetic association between the interleukin-2 receptor-alpha gene and mode of onset of type 1 diabetes in the Japanese population.


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Title: Genetic association between the interleukin-2 receptor-alpha gene and mode of onset of type 1 diabetes in the Japanese population.
Authors: Kawasaki, Eiji / Awata, Takuya / Ikegami, Hiroshi / Kobayashi, Tetsuro / Maruyama, Taro / Nakanishi, Koji / Shimada, Akira / Uga, Miho / Kurihara, Susumu / Kawabata, Yumiko / Tanaka, Shoichiro / Kanazawa, Yasuhiko / Eguchi, Katsumi
Issue Date: Mar-2009
Publisher: The Endocrine Society
Citation: The Journal of clinical endocrinology and metabolism, 94(3), pp.947-952; 2009
Abstract: CONTEXT/OBJECTIVE: The IL-2 receptor-alpha (IL2RA), also known as CD25, is expressed on the regulatory T cells, which play an important role in the control of immune responses and the maintenance of immune homeostasis. Our objective was to determine whether variants in the IL2RA gene are associated with type 1 diabetes in the Japanese population. DESIGN/PATIENTS: We genotyped the four single-nucleotide polymorphisms (rs706778, rs3118470, ss52580101, and rs11594656) of the IL2RA in 885 patients with type 1 diabetes and 606 control subjects of Japanese origin. The allele and genotype frequencies were examined in the patient groups stratified by their mode of onset in a case-control study. RESULTS: We found evidence of association with acute-onset, but not slow-onset and fulminant, type 1 diabetes for two of the four single-nucleotide polymorphisms genotyped (rs706778 and rs3118470). The rs706778 A allele and the rs3118470 G allele were associated with an increased disease risk [odds ratio (OR) for rs706778 AA genotype 1.54, P = 4.2 x 10(-4) and OR for rs3118470 GG genotype 1.50, P = 0.0019, respectively]. Furthermore, the A-G haplotype was associated with increased type 1 diabetes risk in the acute-onset form (OR 1.30, P = 0.002). CONCLUSIONS: The present data confirm the type 1 diabetes association with IL2RA and provide evidence that the different contributions of the IL2RA in the susceptibility to acute-onset and other forms of type 1 diabetes in the Japanese population.
Keywords: IL2RA / Genetics / Japanese / Type 1 diabetes / Mode of onset / HLA / CTLA4
URI: http://hdl.handle.net/10069/23103
ISSN: 0021972X
DOI: 10.1210/jc.2008-1596
PubMed ID: 19106270
Rights: Copyright © 2009 by The Endocrine Society
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/23103

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