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Type B Insulin Resistance Complicated with Systemic Lupus Erythematosus


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Title: Type B Insulin Resistance Complicated with Systemic Lupus Erythematosus
Authors: Kawashiri, Shin-ya / Kawakami, Atsushi / Fujikawa, Keita / Iwamoto, Naoki / Aramaki, Toshiyuki / Tamai, Mami / Nakamura, Hideki / Origuchi, Tomoki / Ida, Hiroaki / Eguchi, Katsumi
Issue Date: 2010
Publisher: The Japanese Society of Internal Medicine / 日本内科学会
Citation: Internal Medicine, 49(5), pp.487-490; 2010
Abstract: Type B insulin resistance is characterized by the appearance of autoantibodies to the insulin receptor. We present a 59-year-old Japanese man with type B insulin resistance complicated with systemic lupus erythematosus (SLE). A high titer of anti-insulin receptor autoantibodies was revealed when SLE was defined as active disease. Intravenous boluses of cyclophosphamide (IVCY) with oral prednisolone and cyclosporin A induced remission of SLE, and a subsequent disappearance of anti-insulin receptor autoantibodies, followed by a recovery of glucose intolerance. This is a rare and important case report showing a clear correlation between anti-insulin receptor autoantibodies of type B insulin resistance and SLE disease activity.
Keywords: Anti-insulin receptor antibody / Systemic lupus erythematosus / Type B insulin resistance
URI: http://hdl.handle.net/10069/23112
ISSN: 09182918
DOI: 10.2169/internalmedicine.49.2746
Rights: © 2010 The Japanese Society of Internal Medicine.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/23112

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