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The Uteroglobin Gene G38A Polymorphism Is Not Associated with Kawasaki Disease


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タイトル: The Uteroglobin Gene G38A Polymorphism Is Not Associated with Kawasaki Disease
著者: Nakashima, Kazuhisa / Ikeda, Kazuyuki / Nishimura, Shinji / Shibata, Yoshisada / Motomura, Hideki / Ohno, Takuro / Zaitsu, Masafumi / Hara, Toshiro / Hamasaki, Yuhei / Moriuchi, Hiroyuki
発行日: 2010年 3月
出版者: Nagasaki University School of Medicine
引用: Acta medica Nagasakiensia, 54(3), pp.53-58 ; 2010
抄録: This study analyzed the genomic DNA extracted from 170 patients with Kawasaki disease as well as their clinical and laboratory parametersto determine whether uteroglobin gene polymorphism, which may be associated with the morbidity rate and severity of IgA nephropathy, is involvedin the pathogenesis of Kawasaki disease, which is another type of vasculitic syndrome in childhood. The uteroglobin genotype at position38 was determined by Sau96I digestion of PCR products. The uteroglobin genotype and allele frequency in Kawasaki disease patientswere compared with those of published control data reported by three independent studies on Japanese individuals. The clinical parametersinvestigated were age at onset, gender, duration of fever, white blood cell count, C-reactive protein, aspartate aminotransferase, alanineaminotransferase and total protein. No significant difference associated with the uteroglobin genotype was observed in the clinical parameters.The genotypic and allele frequencies at position 38 of the uteroglobin gene did not differ significantly in the three studies of Japanese healthycontrols and the present study. The logistic regression analysis demonstrated that no clinical parameter was associated with the progressionto coronary artery lesions except for the duration of fever (odds ratio = 1.7; 95% confidential interval = 1.42-2.05). In conclusion, the presentstudy failed to prove an association of uteroglobin gene polymorphism with the morbidity rate or the severity of Kawasaki disease, but suggestedthe existence of a factor contributing to the onset of Kawasaki disease and progression to coronary artery lesions in Kawasaki diseasepatients.
キーワード: Vasculitis / Coronary artery lesion
URI: http://hdl.handle.net/10069/23118
ISSN: 0001-6055
関連リンク : http://joi.jlc.jst.go.jp/JST.JSTAGE/amn/54.53
資料タイプ: Departmental Bulletin Paper
原稿種類: publisher
出現コレクション:Volume 54, No. 3

引用URI : http://hdl.handle.net/10069/23118

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