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Diffuse Alveolar Hemorrhage following Itraconazole Injection

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Title: Diffuse Alveolar Hemorrhage following Itraconazole Injection
Authors: Izumikawa, Koichi / Nakano, Ken / Kurihara, Shintaro / Imamura, Yoshifumi / Yamamoto, Kazuko / Miyazaki, Taiga / Sakamoto, Noriho / Seki, Masafumi / Ishimatsu, Yuji / Kakeya, Hiroshi / Yamamoto, Yoshihiro / Yanagihara, Katsunori / Tsuchiya, Tomoshi / Yamasaki, Naoya / Tagawa, Tsutomu / Mukae, Hiroshi / Nagayasu, Takeshi / Kohno, Shigeru
Issue Date: 2010
Publisher: The Japanese Society of Internal Medicine / 日本内科学会
Citation: Internal Medicine, 49(5), pp.497-500; 2010
Abstract: Diffuse alveolar hemorrhage (DAH) syndrome is potentially fatal. We encountered a nearly fatal case of DAH possibly due to intravenous itraconazole (ITCZ). A 53-year-old man with chronic pulmonary aspergillosis underwent pneumonectomy of the left lung 15 days prior to the onset of DAH, which was confirmed by bronchoalveloar lavage. The battery of diagnostic evaluations performed revealed no other positive etiological factor, leading to the diagnosis of DAH possibly induced by intravenous ITCZ with a positive drug lymphocyte stimulation test. The patient did not respond to pulse methylprednisolone therapy, but responded dramatically to direct hemoperfusion using a polymyxin B-immobilized fiber column (PMX) therapy.
Keywords: Diffuse alveolar hemorrhage / Intravenous itraconazole / PMX
URI: http://hdl.handle.net/10069/23130
ISSN: 09182918
DOI: 10.2169/internalmedicine.49.2735
Rights: © 2010 The Japanese Society of Internal Medicine.
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/23130

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