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Roles of calcineurin and Crz1 in antifungal susceptibility and virulence of Candida glabrata.


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Title: Roles of calcineurin and Crz1 in antifungal susceptibility and virulence of Candida glabrata.
Authors: Miyazaki, Taiga / Yamauchi, Shunsuke / Inamine, Tatsuo / Nagayoshi, Yosuke / Saijo, Tomomi / Izumikawa, Koichi / Seki, Masafumi / Kakeya, Hiroshi / Yamamoto, Yoshihiro / Yanagihara, Katsunori / Miyazaki, Yoshitsugu / Kohno, Shigeru
Issue Date: Apr-2010
Publisher: American Society for Microbiology
Citation: Antimicrobial agents and chemotherapy, 54(4), pp.1639-1643; 2010
Abstract: A Candida glabrata calcineurin mutant exhibited increased susceptibility to both azole antifungal and cell wall-damaging agents and was also attenuated in virulence. Although a mutant lacking the downstream transcription factor Crz1 displayed a cell wall-associated phenotype intermediate to that of the calcineurin mutant and was modestly attenuated in virulence, it did not show increased azole susceptibility. These results suggest that calcineurin regulates both Crz1-dependent and -independent pathways depending on the type of stress.
URI: http://hdl.handle.net/10069/23140
ISSN: 00664804
DOI: 10.1128/AAC.01364-09
PubMed ID: 20100876
Rights: Copyright © 2010, American Society for Microbiology. All Rights Reserved.
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/23140

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