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Spontaneous remission of a non-small cell lung cancer possibly caused by anti-NY-ESO-1 immunity.


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Title: Spontaneous remission of a non-small cell lung cancer possibly caused by anti-NY-ESO-1 immunity.
Authors: Nakamura, Yoichi / Noguchi, Yuji / Satoh, Eiichi / Uenaka, Akiko / Sato, Shuichiro / Kitazaki, Takeshi / Kanda, Tetsuro / Soda, Hiroshi / Nakayama, Eiichi / Kohno, Shigeru
Issue Date: Jul-2009
Publisher: Elsevier Ireland Ltd
Citation: Lung cancer, 65(1), pp.119-122; 2009
Abstract: Spontaneous remission of malignant tumors is rare and the biological mechanism of such remission has not been addressed. We report the case of a 71-year-old Japanese patient with non-small cell lung cancer with a right hilar tumor and pleural dissemination that spontaneously regressed. NY-ESO-1 is a cancer/testis antigen that can elicit specific immune responses in patients with cancer. Strong anti-NY-ESO-1 immunity was detected in this patient. His tumor cells expressed NY-ESO-1 and MHC class I molecules. Anti-NY-ESO-1 immunity might have contributed to spontaneous remission in this patient.
Keywords: Non-small cell lung cancer / NY-ESO-1 / Spontaneous remission
URI: http://hdl.handle.net/10069/23183
ISSN: 01695002
DOI: 10.1016/j.lungcan.2008.12.020
PubMed ID: 19193472
Rights: Copyright © 2008 Elsevier Ireland Ltd All rights reserved.
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/23183

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