DSpace university logo mark
Advanced Search
Japanese | English 

NAOSITE : Nagasaki University's Academic Output SITE > Graduate School of Biomedical Sciences > Articles in academic journal >

A case of primary Sjögren's syndrome complicated with inflammatory myopathy and interstitial lung disease.


File Description SizeFormat
RheInt_Koga.pdf256.43 kBAdobe PDFView/Open

Title: A case of primary Sjögren's syndrome complicated with inflammatory myopathy and interstitial lung disease.
Authors: Koga, Tomohiro / Kouhisa, Yukiko / Nakamura, Hideki / Mizokami, Akinari / Motomura, Masakatsu / Kawakami, Atsushi / Eguchi, Katsumi
Issue Date: 2010
Publisher: Springer Berlin
Citation: Rheumatology international, Article in Press
Abstract: We experienced a case of a 63-year-old woman with primary Sjögren's syndrome (pSS) complicated with inflammatory myopathy and interstitial lung disease (ILD). She had suffered from morning stiffness and dry mouth for 1 year without being medically examined. A chest CT scan demonstrated ground glass opacity and a reticular shadow in the lower lung field. A diagnosis of SS was made based on positive findings from Schirmer's test, sialography of the parotid gland, a labial salivary gland biopsy and the presence of anti-SS-A antibody. Musculoskeletal symptoms were absent; however, the elevation of creatine kinase (CK) as well as magnetic resonance imaging (MRI)-proven inflammatory change of bilateral muscles of the thigh was evident. Histological examination of the thigh revealed diameter variation, degeneration of muscle fibers and inflammatory cell infiltration in the perivascular area, corresponding to the inflammatory myopathy of pSS. Oral prednisolone 30 mg/day was introduced, and serum CK rapidly decreased within 2 weeks. ILD also responded well to prednisolone without relapse. These clinical outcomes are consistent with extraglandular organ involvement of pSS.
Description: The original publication is available at www.springerlink.com
Keywords: Inflammatory myopathy / Interstitial lung disease / Magnetic resonance imaging / Sjögren's syndrome
URI: http://hdl.handle.net/10069/23190
ISSN: 01728172
DOI: 10.1007/s00296-010-1517-z
PubMed ID: 20461384
Rights: © Springer-Verlag 2010
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/23190

All items in NAOSITE are protected by copyright, with all rights reserved.

 

Valid XHTML 1.0! Copyright © 2006-2015 Nagasaki University Library - Feedback Powerd by DSpace