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Relationship between microvessel count and postoperative survival in patients with intrahepatic cholangiocarcinoma.


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Title: Relationship between microvessel count and postoperative survival in patients with intrahepatic cholangiocarcinoma.
Authors: Nanashima, Atsushi / Shibata, Kenichiro / Nakayama, Toshiyuki / Tobinaga, Syuichi / Araki, Masato / Kunizaki, Masaki / Takeshita, Hiroaki / Hidaka, Shigekazu / Sawai, Terumitsu / Nagayasu, Takeshi / Tagawa, Tsutomu
Issue Date: Aug-2009
Publisher: Springer New York
Citation: Annals of Surgical Oncology, 16(8), pp.2123-2129; 2009
Abstract: BACKGROUND: The present study aimed to elucidate the relationship between microvessel count (MVC) according to CD34 expression and prognosis in intrahepatic cholangiocarcinoma (ICC) patients who underwent hepatectomy based on our preliminary study. METHODS: Relationships between MVC and clinicopathological factors were examined in 37 ICC patients. CD34 expression was analyzed using immunohistochemical methods. RESULTS: Median MVC for ICC patients was 140/mm(2), which was applied as a cutoff value. Lower MVC was significantly associated with larger tumor size, periductal infiltrating type, and advanced Japanese tumor-node-metastasis stage (p < 0.05). Univariate survival analysis identified higher carcinoembryonic antigen level, periductal infiltrating type, poor histological differentiation, and lower MVC as significantly associated with lower 5-year survival rates. The 5-year survival rate in the higher-MVC group was significantly greater than that in the lower-MVC group (44% vs. 7%, p = 0.048). According to Cox multivariate survival analysis, only periductal infiltrating type on macroscopic examination was identified as a significant independent risk factor for poor survival after hepatectomy (risk ratio 4.8; p = 0.006), not MVC (1.1; p = 0.82). CONCLUSION: Tumor MVC might offer a useful prognostic marker of ICC patient survival after hepatectomy and further investigation in a larger series is warranted.
Keywords: intrahepatic cholangiocarcinoma / hepatic resection / microvessel count / CD34
URI: http://hdl.handle.net/10069/23196
ISSN: 10689265
DOI: 10.1245/s10434-009-0494-5
PubMed ID: 19434454
Rights: © 2009 Society of Surgical Oncology.
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/23196

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