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Familial Creutzfeldt-Jakob disease with a V180I mutation: comparative analysis with pathological findings and diffusion-weighted images.

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Title: Familial Creutzfeldt-Jakob disease with a V180I mutation: comparative analysis with pathological findings and diffusion-weighted images.
Authors: Mutsukura, Kazuo / Satoh, Katsuya / Shirabe, Susumu / Tomita, Itsuro / Fukutome, Takayasu / Morikawa, Minoru / Iseki, Masachika / Sasaki, Kensuke / Shiaga, Yusei / Kitamoto, Tetsuyuki / Eguchi, Katsumi
Issue Date: Dec-2009
Publisher: S. Karger AG
Citation: Dementia and geriatric cognitive disorders, 28(6), pp.550-557; 2009
Abstract: BACKGROUND: Diffusion-weighted imaging (DWI) has been reported to be a useful technique for diagnosing Creutzfeldt-Jakob disease (CJD). The present study reported DWI results in cases of familial CJD with a V180I mutation (CJD180) in the prion protein gene as well as neurological findings. METHODS: A retrospective analysis of 3 patients with V180I was performed. Cerebrospinal fluid (CSF) analysis, brain MRI, single-photon emission computed tomography (SPECT), and magnetic resonance spectroscopy (MRS) were included. CSF was analyzed for biochemical markers, and each patient underwent brain MRI, SPECT, and MRS analysis. A brain biopsy from the frontal cortex, which corresponded to the area of increased DWI signals, was utilized for neuropathological analysis. RESULTS: CSF analysis results revealed elevated total tau protein and the absence of 14-3-3 protein, as well as decreased concentrations of neuron-specific enolase, S100 protein, and prostaglandin E(2). All patients presented with unique MRI features. Brain biopsy showed severe spongiform morphology, but comparatively preserved neurons and mild astrocytic gliosis. Accumulations of PrP(Sc) were not detected using the 3F4 antibody, and microglial activation was subtle. SPECT revealed hypoperfusion throughout both hemispheres. MRS revealed a reduced N-acetyl aspartate/creatine ratio. CONCLUSION: Results from this study suggested that increased DWI signals could reflect severe spongiform changes in CJD180 patients.
Keywords: Creutzfeldt-Jakob disease / Diffusion-weighted imaging / Magnetic resonance spectroscopy / Single-photon emission computed tomography / Brain biopsy
URI: http://hdl.handle.net/10069/23204
ISSN: 14208008
DOI: 10.1159/000254842
PubMed ID: 20051687
Rights: Copyright © 2009 S. Karger AG, Basel
Type: Journal Article
Text Version: author
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/23204

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